愈溃生物黏附单向释药贴膜的质量标准研究  

Quality Standard of Yukui Biological Adhesion One-way Release Membrane

作　　者：段晓颖[1] 高卫芳[2] 平佳宜[1] 张辉[1] 

机构地区：[1]河南中医学院第一附属医院国家中医药管理局中药制剂三级实验室,郑州市450000 [2]新乡医学院第一附属医院,卫辉市453100

出　　处：《中国药房》2011年第47期4460-4462,共3页China Pharmacy

基　　金：河南省科技发展计划项目(072102330035)

摘　　要：目的:建立愈溃生物黏附单向释药贴膜的质量标准。方法:采用薄层色谱(TLC)法对方中牡丹皮、青黛、冰片进行定性鉴别;用高效液相色谱法测定胡黄连中胡黄连苷Ⅰ和胡黄连苷Ⅱ的含量。结果:TLC斑点清晰、分离度好;胡黄连苷Ⅰ、胡黄连苷Ⅱ的检测浓度分别在0.08～0.40、0.12～0.60μg·mL-1(r均为0.9999)范围内与各自峰面积积分值呈良好线性关系,平均回收率分别为100.24%、99.61%,RSD分别为1.72%、1.76%(n均为9)。结论:所建标准可用于愈溃生物黏附贴膜的质量控制。OBJECTIVE： To establish the quality standard of Yukui biological adhesion one-way release membrane. METHODS： Paeonia suffruticosa, Indigo Naturalis and Bomeolum Syntheticum in Yukui biological adhesion one-way release membrane were identified by TLC; and the contents of picroside Ⅰ and picroside Ⅱ in Picrorhiza scrophulariiflora were determined by HPLC. RESULTS： TLC spots were distinctive and well-separated. The linear ranges of picroside I and picrosid Ⅱ were 0.08～0.40μg. mL-1 （r=-0.999 9） and 0.12～0.60μg.mL-1（r=0.999 9）,respectively. Their average recovery rates were 100.24% （RSD=1.72% ,n=9） and 99.61% （RSD=1.76%, n=9）. CONCLUSION： Established standard is applicable for the quality control of Yukui biological adhesion membrane.

关 键 词：愈溃生物黏附贴膜 质量标准 薄层色谱法 高效液相色谱法 胡黄连苷Ⅰ 胡黄连苷Ⅱ 

分 类 号：R283.69[医药卫生—中药学] R927.2[医药卫生—中医学]