胸腺五肽及其聚乙二醇衍生物的固相合成  

SOLID PHASE SYNTHESIS OF THYMOPENTIN PENTAPEPTIDE AND PEGYLATED THYMOPETIDUM

作　　者：韩月[1] 王良友[1] 尹志峰[1] 高杨[1] 赵红玲[1] 吕逢春[1] 

机构地区：[1]承德医学院中药研究所,河北承德067000

出　　处：《承德医学院学报》2011年第4期351-353,共3页Journal of Chengde Medical University

摘　　要：目的:Fomc法固相优化合成胸腺五肽(TP5)并对其进行聚乙二醇(PEG)修饰,以延长TP5在体内的半衰期。方法:采用固相合成技术合成PEG化TP5,高效液相色谱进行分析和纯化,氨基酸测序仪测序。结果:经鉴定,合成的TP5和PEG化TP5与理论值一致。结论:该方法操作简单、成本低,得到的产品纯度较高、易于纯化。Objective：To optimize the solid phase synthesis method of thymopentin pentapeptide （TP5） and synthesize pegylated TP5, so lengthen the half life period of TP5.Methods：Solid phase synthesis was used to synthesize TP5, high-performance liquid chromatography to analyze and purify, protein sequencer to detect the sequence of amino acid.Results：Tbe TP5 and pegylation TP5 was in conformity with theoretical value.Conclusions：This craft is convenient and low cost, the purity of products is fairly high and the product is easy to be purified.

关 键 词：胸腺五肽 聚乙二醇化 固相合成 

分 类 号：Q78[生物学—分子生物学]