微波辐照诱发Wistar大鼠外周血淋巴细胞亚群变化  

Effects of Microwave Radiation on Lymphocyte Subpopulations in Rat Peripheral Blood

作　　者：尹金玲[1] 满其航[1] 崔玉芳[2] 杜丽[2] 马琼[2] 

机构地区：[1]航天中心医院职业病科,北京100049 [2]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《辐射防护通讯》2011年第4期19-22,共4页Radiation Protection Bulletin

基　　金：国家自然科学基金(39000386);毫米波国家重点实验室开放课题(K200909);军队医药卫生"十一五"基金(09MA026)

摘　　要：采用微波辐照雄性清洁级Wistar大鼠,观察其对大鼠外周血淋巴细胞亚群的影响。实验结果显示:与对照组相比,10 mW/cm2组、30 mW/cm2组照射后第7天,5 mW/cm2组1、0 mW/cm2组3、0 mW/cm2组照射后第14天,CD3+降低显著;10 mW/cm2组照射后第14天,CD4+降低显著。各辐照组照射后第1、7、14天,CD8+均降低,其中,30 mW/cm2组降低显著;5 mW/cm2组照射后第1天,5 mW/cm2组、30 mW/cm2组照射后第14天,CD4+/CD8+比值降低显著。与T淋巴细胞变化趋势相反,与对照组相比,微波辐照后,各剂量照射组B淋巴细胞CD45RA+均升高,其中,30 mW/cm2照射后第1天,30 mW/cm2组6、0 mW/cm2组照射后第14天,升高显著,并且在照射后第14天,CD45RA+随照射剂量的升高而升高。结果提示,一定剂量的微波辐照能诱发大鼠外周血淋巴细胞亚群比例的改变,导致免疫功能受损。CD3 ＋ cells in 10 - 30 mW/cm2 groups at 7 d and in 5 - 30 mW/cmz groups at 14 d and CD4＋ T subset in 10 roW/cm2 group at 14 d post radiation were all decreased signifieantiy as compared with control groups. 1 to 14 d after radiation, CD8＋ T cells in all irradiated groups showed reduction, however, only that in 30 mW/cm2 group reduced statistically when compared with control group. CIM＋/CD8＋ ratios in 5 mW/cm2 group at ld and in 5 - 30 mW/cm2 groups at 14 d post radiation were all diminished statistically as compared with control groups. After microwave exposure, CIM5RA＋ B cells showed opposite change to the T cells, for instance, CD45RA＋ B cells in 30 mW/emz group at 1 d and in 30 - 60 mW/cm2 groups at 14 d post radiation increased significantly, which showed better dose-effect relationship 14 d after irradiation.

关 键 词：微波 淋巴细胞 大鼠 

分 类 号：R818.02[医药卫生—放射医学]