高效液相法检测硬膜外隙注射用药混合后理化性质变化的研究  

Detection of Physical and Chemical Properties of Epidural Injection Medication Mix-gap with High Performance Liquid Chromatograph

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作  者:徐亮 杨伍 徐阳平[3] 黄利民 

机构地区:[1]武汉市三医院重症医学科,武汉430060 [2]武汉同济现代医药有限公司 [3]湖北省中医院光谷院区骨科

出  处:《中国中医骨伤科杂志》2011年第12期4-6,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基  金:武汉市卫生局科研2009年度基金项目

摘  要:目的:观察临床上常用的硬膜外腔隙注射配方用药混合后是否发生相互影响而降低各自的有效成分而存在配伍禁忌。方法:采用自身对照研究方法,对临床上采用较多的维生素B12注射液、地塞米松磷酸钠注射液、碳酸利多卡因注射液、盐酸利多卡因注射液、注射用甲泼尼龙琥珀酸钠分别组成的4组混合液配方并通过PH测定及高效液相法(HPLC)对药物的理化性质和含量进行了对比研究。结果:各组混合液在室温及36.5℃的恒温下,并未出现沉淀变色,PH值均未发生明显变化,理化性质稳定。各组混合液的HPLC分析发现,各组分混合液在混合前后峰面积值均无明显变化,且混合液中无新的杂质峰产生。结论:在本试验条件下,各组配方药物混合后,理化性质稳定,混合液中各种药物有效成分未改变,未出现配伍禁忌。而其作用对神经痛的治疗机制仍有待进一步研究。Objective:To observe the drug interaction which used admixture in the epidural space injection, leading to reduce the active of each ingredient, so to conform there was incompatibility. Methods:The selPcontrol study was used. The physical and chemical prop- erties and the contents of drugs which mixed of vitamin B12 injection, dexamethasone sodium phosphate injection, carbonated lidocaine injection, lidocaine hydrochloride injection, and methylprednisolone sodium succinate injection were detected and analyzed by PH and high performance liquid chromatography (HPLC) method. Results:The mixed drugs did not show discoloration, its PH value was not significant change, and its physical and chemical properties were stable at room temperature and under constant temperature of 36. 5 ℃. The HPLC analysis showed that the peak area was not changed in each compounded liquid before and after mixed, and there was no impure peak. Conclusion:In this experiment, the properties of physical and chemical and the active ingredient of the compounded drugs are not changed, and there is no incompatibility. The mechanisms in treatment of neuropathic pain remains to be further studied.

关 键 词:高效液相 硬膜外间隙 药物 

分 类 号:R961[医药卫生—药理学]

 

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