下呼吸道肺炎克雷伯菌ESBLs的检测及耐药性分析  

Lower Respiratory Tract Klebsiella Pneumoniae Infection:Detection and Susceptibility of Tts Extended Spectrum β-lactamase

作　　者：叶军盼 罗利飞[2] 

机构地区：[1]浙江省天台县中医院呼吸内科,浙江天台317200 [2]浙江省台州医院路桥院区检验科,浙江台州318050

出　　处：《中国现代医生》2011年第34期77-78,共2页China Modern Doctor

基　　金：2008年浙江省台州市科技计划项目(081KY39)

摘　　要：目的探讨下呼吸道感染肺炎克雷伯菌的超广谱β-内酰胺酶(ESBLs)的检测及耐药性分析。方法对下呼吸道感染患者中分离的135株肺炎克雷伯菌的耐药性及产ESBLs菌进行分析。结果从135株肺炎克雷伯菌中检出产ESBLs菌株58株,检出率高达43.0%。除亚胺培南外,产ESBLs菌株对15种抗生素的耐药性均高于非产ESBLs菌株(P<0.01)。结论 ESBLs是下呼吸道感染肺炎克雷伯菌产生耐药性的主要原因,临床上经验用药可选择头霉素类、β-内酰胺类/β-内酰胺酶抑制剂和碳青霉烯类抗生素。Objective To detect and analyze the susceptility of the extend spectrum β-lactamase which was produced by klebsiella pneumoniae in lower respiratory tract infection. Methods All of 135 strains of Klebsiella Pneumoniae separated from patients of lower respiratory infection were choosed,and its susceptibility and ability of ESBLs-producing were analyzed. Results All 58 ESBLs-producing strains were determinded from 135 strains of Klebsiella Pneumoniae （43.0%）.Except Imipinem,the resistant rates of ESBLs producing strains to 15 antibiotics were much higher than thai of non ESBLs producing strains（P〈0.O1）. Conclusion ESBLs-producing maybe the main reason of the drug resistance of klebsiella pneumoniae,so we can clinicly choose antibiotics as kind of cephamycins, β-1ac tams/β-lactamase inhibitors and earbopenems as empirical treatment.

关 键 词：下呼吸道感染 肺炎克雷伯菌 超广谱Β-内酰胺酶 耐药性 

分 类 号：R725.6[医药卫生—儿科]