住院患者中药物性肾病的可疑药物筛选  

Suspected drug screening of drug-induced renal disease in inpatients population

作　　者：姜慧芳[1] 程能能[1] 杜文民[2] 

机构地区：[1]复旦大学药学院药理学教研室,上海201203 [2]上海市药品不良反应监测中心,上海200233

出　　处：《中国临床药学杂志》2011年第6期359-361,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的探讨药物性肾病在我国住院患者人群中发生率及与筛选出其可疑药物。方法利用2009年5月29日至12月31日医院住院患者用药数据库(IDUD)信息,采用数据挖掘技术结合药物流行病学研究方法,计算药物性肾病与可疑药物之间相对危险度。结果共获得药物性肾病的可疑药物130个,其中中药49个。按相对危险度排序,前3位可疑药物分别为扶正化瘀、肾衰宁和精氨酸。结论在住院患者人群中,特别是使用中药的患者,应加强肾功能监测。AIM To investigate the incidence rate and suspected drugs of drag-induced renal disease in inpatients population. METHODS Based on Shanghai inpatients drug utilization database（from May 29,2009 to December 31, 2009） we used data mining technology and methods in pharmacoepidemiology to calculate the odds ratio（OR） of suspect- ed drug in inducing renal disease. RESULTS A total of 130 drugs were suspected as renal disease inducing drugs, a-mong them 49 drugs were Chinese traditional medicine. First 3 drugs on the OR was Fuzhenghuayu , Shenshuaining and arginine. CONCLUSION Medication should be attached to renal function monitoring in inpatients population, especially who is treated with Chinese traditional medicine.

关 键 词：药物性肾病 中药 可疑药物 相对危险度 

分 类 号：R96[医药卫生—药理学]