我院826例手术患者抗菌药物合理用药情况的调查分析  

Investigation and analysis:826 cases of antibacterial drug rational use in the surgical inpatients of our hospital

作　　者：张璞[1] 郭燕萍[1] 王斌 李中东[1] 钟明康[1] 

机构地区：[1]复旦大学附属华山医院药剂科,上海200040

出　　处：《中国临床药学杂志》2011年第6期368-371,共4页Chinese Journal of Clinical Pharmacy

摘　　要：目的评价我院住院手术患者抗菌药物应用情况及其合理性。方法采用回顾性队列研究,在2006-2008年内按《抗菌药物临床应用指导原则实施细则》出台前后半年及我院实施合理用药机制后半年分成3个阶段,每个阶段随机抽取500例住院患者,对其手术患者病历进行收集分析,评价临床抗菌药物使用的合理性。结果与第一阶段相比,第二阶段的抗菌药物使用金额有所下降,用药天数明显缩短,在预防用药给药疗程和时间、联合用药指征、品种上更为合理;与第二阶段相比,第三阶段用药种类数有所下降,在预防用药类别、疗程和时间、细菌培养和药敏试验、根据药敏结果调整上更加合理。结论《抗菌药物临床应用指导原则实施细则》的出台一定程度降低了抗菌药物在临床的使用量,减少了患者的住院天数,并减少了不合理用药事件的发生,节约了医疗资源。同时通过药师参与临床及各种机制的建立,能够明显加强政策的落实,促进抗菌药物的进一步合理应用。AIM To analyze and evaluate the status of antibacterial usage in the surgical inpatients of Shanghai Huashan hospital. METHODS By using a retrospective study, the medical records of surgical inpatients in three phases from 2006 to 2008 were collected and analyzed to evaluate the rationality of antibacterial usage. RESULTS It showed that the cost of antibacterial was slightly decreased in phase 2, while the duration of usage was dramatically dropped in phase 2. In addition, drug categories appeared the trend of decreasing in phase 3. Compared with phase 1, phase 2 showed better results in terms of the medication duration and time of prophylactic utilization, the indications of drug com- bination, and categories. In contrast, phase 3 demonstrated that drug categories, the duration of prophylactic utilizations, bacterial cultures and drug sensitive tests, and medication adjusmaents were more preferable than phase 2. CONCLUSION By referring the Clinical Guidelines and Indications for the Use of Antibacterial, it is able to reduce the consumption of antibacterial, the duration of hospitalization, and the incidence of irrational administration to some extent; hence, it saves medical resources correspondingly. In addition, the clinical involvement of pharmacists and the adoption of relative regulations may strengthen the implement of the guidelines and ensure rational use of antibacterial.

关 键 词：抗菌药物 指导原则 合理用药 

分 类 号：R95[医药卫生—药学]