透明质酸的改性及临床应用  

Modification and Clinical Application of Hyaluronic Acid

作　　者：曹亚虹[1] 郝红[1] 韦雄雄[1] 梁建国[1] 黄程[2] 

机构地区：[1]西北大学化工学院,西安710069 [2]湖南大学化学与化工学院,长沙410082

出　　处：《高分子通报》2011年第12期50-55,共6页Polymer Bulletin

基　　金：人事部留学人员科技活动择优项目(SLZ2009011);陕西省13115科技创新工程重大科技专项项目(2007ZDKG-50)资助

摘　　要：透明质酸具有极高的保湿性、粘弹性、润滑性、生物相容性和生物降解性,在医药、组织工程及临床医学中得到广泛应用。但天然HA稳定性差,对强酸、强碱、热及透明质酸酶敏感等缺陷限制了其在临床上的应用,因此改性HA的研究越来越受到关注。本文综述了近年来国内外采用交联、酯化、复合/共聚等方法对HA的改性研究,介绍了HA及衍生物在眼科手术、声外科手术、骨关节炎治疗、防术后粘连和药物输送系统等临床应用情况,并对其发展前景进行展望。Hyaluronic acid is widely used for medical field, tissue engineering and clinical medicine due to its excellent moisture retention, viscoelasticity, lubricity, biocompatibility and biodegradability. The unstability and sensitivity of natural HA to strong acid, base, heat and hyaluronidase limit its clinical application, so the research on modificated HA has been paid more attention. This review concentrates on the recent research achievement on the preparation of HA derivatives by corss-linking, esterification, composition and copolymerization, as well as their clinical application especially in ophthalmic surgery,phonosurgery,osteoarthritis treatment and drug delivery system.

关 键 词：透明质酸 改性 生物相容性 生物降解性 临床应用 

分 类 号：R318.08[医药卫生—生物医学工程]