骨化三醇治疗佝偻病的疗效  

Calcitriol Therapy for Treating Vitamin D Deficiency Rickets in Children

作　　者：于立君[1] 杜秋影[1] 姚笠[1] 

机构地区：[1]哈尔滨医科大学附属第二医院儿内科,哈尔滨150086

出　　处：《实用儿科临床杂志》2011年第23期1829-1830,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨骨化三醇治疗小儿佝偻病的效果。方法选取150例1～3岁的佝偻病患儿,随机分为3组,每组50例,治疗1组每日口服骨化三醇1粒(0.25μg),治疗2组每日2粒(0.50μg),对照组则每日给予普通维生素D2 2 000 IU。治疗1个月后比较各组患儿治疗前后临床表现(夜惊、多汗、烦闹、枕秃等)改善情况,以及身高、血清钙、骨碱性磷酸酶(BALP)、血清25羟维生素D3、骨密度的变化情况。采用SPSS 13.0软件进行统计学分析。结果各组患儿临床表现(夜惊、多汗、烦闹、枕秃)均有改善;各组患儿身高、体质量均有增长,组间比较均无统计学差异;三组间血清钙比较无统计学差异;治疗后BALP下降、血清25羟维生素D3水平及骨密度升高,与治疗前比较差异均有统计学意义(Pa<0.01),治疗2组最明显。结论骨化三醇治疗儿童佝偻病疗效显著,0.50μg.d-1对北方地区儿童佝偻病能够起到治疗作用。Objective To observe calcitriol for treating infantile vitamin D deficiency rickets in children. Methods One hundred and fifty infants with vitamin D deficiency rickets were randomly divided into three groups,treatment group 1（50 cases）,were treated with oral calcitriol 0.25 μg·d-1 for 30 days;treatment group 2（50 cases）,were treated with 0.50 μg·d-1 for 30 days;and treatment group 3（50 cases）,were treated with vitamin D2 2 000 IU·d-1 for 30 days.The changes in correlation symptoms（night terrors,sweat,vexed make,pillow bald）,height and weight,serum calcium,bone alkaline phosphatase（BALP）,serum 25-（OH） vitamin D3 and changes in the bone mineral density were observed in 3 groups.SPSS 13.0 software was used to analyze the data. Results The clinical symptoms（night terrors,sweat,vexed make,pillow bald） in each group were all improved;height,weight in each group also grew and had no statistical difference among them;the serum calcium in 3 groups had no statistical difference.After treatment,the decline of BALP and the increase of serum 25-（OH） vitamin D3 and bone mineral density had statistically significant changes（Pa〈0.01）.Treatment group 2 changed the most. Conclusion Treatment of calcitriol in infantile rickets has curative effect,and 0.50 μg·d-1 in northern area children is proved to be a very good therapy.

关 键 词：骨化三醇 佝偻病 维生素D缺乏 骨碱性磷酸酶 骨密度 

分 类 号：R723.2[医药卫生—儿科]