雷公藤总苷对紫癜性肾炎患儿血清肿瘤坏死因子-α和白细胞介素-8水平的影响  

Effect of Tripterygium Glycosides on Levels of Tumor Necrosis Factor-α and Interleukin-8 in Serum of Children with Henoch-Schonlein Purpura Nephritis

作　　者：郭蕴琦[1] 裴利宏[2] 

机构地区：[1]新乡医学院第一附属医院药剂科,河南卫辉453100 [2]新乡医学院第一附属医院检验科,河南卫辉453100

出　　处：《实用儿科临床杂志》2011年第23期1831-1832,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨雷公藤总苷治疗儿童紫癜性肾炎(HSPN)的临床药理疗效及对血清TNF-α和IL-8水平的影响。方法 38例HSPN患儿随机分为2组,对照组18例给予抗血小板聚集、抗组胺、低分子肝素钠、泼尼松等常规治疗,而治疗组20例在此基础上加用雷公藤总苷片治疗,每日1.5 mg.kg-1,连用4周。观察2组的临床治疗效果及皮肤紫癜、24 h尿蛋白定量、尿沉渣分析的变化,采用放射免疫法检测其治疗前后血清TNF-α和IL-8水平变化,采用SPSS 11.5进行统计学分析。结果治疗组临床总有效率高于对照组(χ2=10.526,P<0.05);两组患儿治疗后血清TNF-α和IL-8水平均下降,其中以治疗组下降更明显,差异有统计学意义(P<0.01)。结论雷公藤总苷对儿童HSPN有较好疗效,其机制可能和抑制血清TNF-α和IL-8水平有关。Objective To observe the pharmacological effect of tripterygium glycosides treatment on children with Henoch-Schonlein purpura nephritis（HSPN） and the change in serum levels of TNF-α and IL-8. Methods Thirty-eight patients diagnosed as HSPN were randomly divided into a control group（18 patients,oral drug：antiplatelet aggregating,antihistamine,low-molecular-weight heparin sodium,joint prednisone） and a treatment group（20 cases,add tripterygium glcosides 1.5 mg·kg^-1·d^-1,last for 4 weeks）.The effect of drug treatment and the changes in skin purpura,24-hour proteinuria quantity,urinary sediment analysis were observed.The serum levels of TNF-α and IL-8（consisting the before and behind of treatment） were detected by using radio-immunity analysis,moreover,data of the two groups were compared.SPSS 11.5 software was used to analyze the data. Results The total clinical effective rate in treatment group was higher that in the control group（χ2=10.526,P〈0.05）,serum levels of TNF-α and IL-8 in two groups were all decreased,but the levels in treatment group decreased more than that in the control group obviously,and the difference was significant（P〈0.01）. Conclusions The clinical pharmacology effection of tripterygium glycosides treatment on children with HSPN is efficient,and it can suppress the serum levels of TNF-α and IL-8.

关 键 词：紫癜性肾炎 雷公藤总苷 肿瘤坏死因子-Α 白细胞介素-8 儿童 

分 类 号：R726.9[医药卫生—儿科]