胆固醇酯转运蛋白基因-1337C/T多态与血脂异常及辛伐他汀疗效的相关性  

Association between-1337C/T polymorphism in CETP gene with dyslipidemia and the lipid-regulating effects of simvastatin

作　　者：李俊涛[1,2] 王敏[2] 李果明[3] 郑克勤[1] 

机构地区：[1]广东医学院医学遗传学研究室,广东湛江524023 [2]肇庆医学高等专科学校,广东肇庆526020 [3]广东医学院附属医院心内科,广东湛江524023

出　　处：《中国药理学通报》2011年第12期1714-1717,共4页Chinese Pharmacological Bulletin

基　　金：广东省自然科学基金资助项目(No 04011388)

摘　　要：目的探讨辛伐他汀调血脂效果与胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)基因启动子区-1337C/T单核苷酸多态性的相关性。方法采用聚合酶链反应-限制性片段长度多态性方法检测315例经辛伐他汀调脂治疗的血脂异常患者CETP基因-1337C/T多态性位点的基因型频率分布情况,并比较各项血脂水平及辛伐他汀调脂治疗效果与该多态位点基因型之间的关系。结果高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平的改变量在-1337C/T多态各基因型组间差异有显著性(F=3.767,P=0.025),CC基因型患者HDL-C升高的幅度较之CT和TT基因型患者明显多出了0.098 mmol.L-1和0.139 mmol.L-1(P<0.05,P<0.01)。结论辛伐他汀调血脂效果与CETP基因-1337C/T多态性有关联。Aim To investigate the association between the lipid-regulating effect of simvastatin with - 1337C/ T polyrnorphism in CETP gene. Methods The target DNA fragments of CETP gene were amplified and analyzed by PCR-RFLP technique in 315 dyslipidemia patients treated with simvastatin. The relationship between - 1337C/T polymorphism and each blood-fat index was analyzed by SPSS statistic software. Results The HDL-C rising extent was significantly different （F = 3.767 ; P = 0. 025 ） between - 1337C/T genotypes, respectively. The HDL-C rising extent was 0. 098 mmol . L-1 and 0. 139 mmol. L-1（P 〈0.05, P 〈 0. 01 ） higher in CC individuals than in CT and TT individuals. Conclusion CETP gene -1337C/T polymorphism is associated with the lipid-regulating effect of simvastatin.

关 键 词：辛伐他汀 胆固醇酯转运蛋白基因 血脂异常 高密 度脂蛋白胆固醇 极低密度脂蛋白胆固醇 单核苷酸多态性 

分 类 号：R341.35[医药卫生—基础医学] R344.81