C_(60)-肌肽衍生物的制备及其抗氧化性研究  

Synthesis and Oxidation Resistance of Carnosine C_(60) Derivatives

作　　者：孙涛[1,2] 孙斐[1] 巢骏[1] 谢晶[1] 周冬香[1] 

机构地区：[1]上海海洋大学食品学院,上海201306 [2]上海海洋大学海洋科学研究院,上海201306

出　　处：《湖南农业科学》2011年第11期71-75,共5页Hunan Agricultural Sciences

基　　金：上海市生物医药和农业科技领域重点科技项目(08391911500);上海市优秀学科带头人计划(09XD1402000);上海市教育委员会重点学科建设项目(J50704)

摘　　要：通过控制反应物C60以及肌肽的量,合成了三种水溶性C60-肌肽衍生物。采用红外、紫外、核磁共振、元素分析等手段对其结构进行了表征;同时考察了它们对超氧阴离子自由基、羟基自由基的清除能力、还原能力及金属螯合能力。结果表明:随着反应物中肌肽含量的增多,制得C60-肌肽衍生物的抗氧化能力增强,这可能与-NH基的供电效应有关。Three water-soluble carnosine C60 derivatives were synthesized by controlling the reaction ratio of C60 and carnosine. The products were characterized by FT-IR, UV, IH NMR and elemental analysis; meanwhile, theirs scavenging ability, reducing power and metallic chelating ability on free superoxide anion radical and free hydroxyl radical were studied. The results showed that the oxidation resistance of carnosine C60 derivatives increased with increasing carnosine content in reaction, which might relate to the electron donating effect of-NH groups.

关 键 词：C60-肌肽衍生物 超氧阴离子 羟基自由基 还原能力 金属螯合能力 

分 类 号：O621[理学—有机化学]