紫茎泽兰醇提取物对大鼠致畸作用  

Teratogenic effect of Euratorium adenophorum spreng extract in rats

作　　者：李厚勇[1] 王蕊[1] 张振铃[1] 徐明[1] 王蓉[1] 修海迪[1] 

机构地区：[1]山东省职业卫生与职业病防治研究院,济南250062

出　　处：《中国公共卫生》2011年第12期1593-1594,共2页Chinese Journal of Public Health

基　　金：国家公益性行业科研专项(200803021)

摘　　要：目的探讨紫茎泽兰醇提取物对大鼠致畸作用。方法按照《农药登记毒理学试验方法》,将孕鼠随机分为5组,紫茎泽兰高、中、低剂量组(分别于孕第6～16 d经口灌胃给予1 000、500、200 mg/kg紫茎泽兰醇提取物),阴性对照组(蒸馏水),阳性对照组(阿司匹林300 mg/kg)。于妊娠第20 d处死孕鼠,观察孕鼠生殖情况和胎鼠生长发育、骨骼内脏畸形情况。结果紫茎泽兰中、高剂量组吸收胎率分别为15.08%和7.62%,与阴性对照组比较,差异有统计学意义(P<0.05),其它各剂量紫茎泽兰组孕鼠进食、活动、体重增长、死胎率均未见明显影响;与阴性对照组比较,胎鼠体重、身长、尾长无明显差异(P>0.05);胎鼠外观、骨骼、内脏检查均未发现明显畸形。结论紫茎泽兰醇提取物具有一定胚胎毒性,无明显致畸作用。Objective To study the teratogenicity of Euratorium adenophorum spreng extract in rats.MethodsAccording to toxicological test methods of pesticides for registration,the pregnant rats were divided into 5 groups：three Euratorium adenophorum spreng extract dosage groups（1000,500,200 mg/kg）,negative control group and positive control group（300 mg/kg aspirin）.Euratorium adenophorum spreng extract and aspirin were given orally from 6th to 16th day of gestation.The pregnant rats were sacrificed on the 20th day of gestation.Embryonic and fetal developmental parameters were surveyed.The appearance,viscera and skeleton of the fetuses were examined.Results Absorbed fetus rate in moderate and high dose groups was 7.62% and 15.08%,showing obvious increases compared with negative control group.There was no difference in the rate of fetal mortality and weight gain in all treated and negative control group.The weight,body length and tail length showed no significant difference between the treated groups and negative control group.Euratorium adenophorum spreng extract didn＇t induce obvious teratogenic effect on the appearance,viscera and skeleton of the fetuses.Conclusion Euratorium adenophorum spreng extract exert a certain embryotoxicity,but has no apparent teratogenicity in rats.

关 键 词：紫茎泽兰 致畸作用 母体毒性 胚胎毒性 

分 类 号：R994.6[医药卫生—毒理学]