冠心病患者血清总胆红素水平的Meta分析  

A Meta-analysis of serum total bilirubin concentration in patients with coronary heart disease

作　　者：史连义[1,2] 周志伟[1,2] 田雪梅[1,2] 张继领[1,2] 刘继勇[1,2] 杨保昌[1,2] 马春华[1,2] 

机构地区：[1]中国石油天然气集团公司中心医院 [2]河北医科大学石油临床学院,河北廊坊065000

出　　处：《国际检验医学杂志》2011年第18期2062-2064,共3页International Journal of Laboratory Medicine

基　　金：廊坊市科技局科技支撑项目(2010013029)

摘　　要：目的探讨血清胆红素水平与冠心病的关系。方法检索中国知网、万方、维普数据库关于冠心病与血清总胆红素水平关系的对照研究,以此作为基础文献,数据以RevMan 4.2软件进行Meta分析。结果共收集到符合要求的文献26篇,漏斗图显示文献无发表偏倚,Meta分析结果显示冠心病患者较健康者血清总胆红素水平低(P<0.01),多支病变组较双支病变组及单支病变组血清总胆红素水平低(P<0.01),双支病变组较单支病变组血清总胆红素水平低(P<0.05)。结论冠心病患者血清总胆红素水平低于健康者,冠状动脉病变越严重血清总胆红素水平越低。Objective To explore the association between coronary heart disease（CHD） and serum total bilirubin concentration（TBIL）.Methods All related case-control studies about the association between CHD and serum TBIL were searched by retrieving on databases of CNKI,Wanfang and VIP.Data from retrieved literatures were analyzed by RevMan4.2 software for analysis.Results 26 literatures,meeting the criterion designed for this study,were included.Funnel plot showed no publication bias.Meta-analysis showed that serum level of TBIL in patients with CHD was significantly lower than in subjects without CHD（P0.00001）,that in CHD patients with multi-vessel affection was significantly lower than in CHD patients with single-vessel or double-vessel affection（P0.00001）,that in CHD patients with double-vessel affection was significantly lower than in CHD patients with single-vessel affection（P=0.02）.Conclusion Serum level of TBIL in CHD patients could be lower than in patients without CHD.The more severe the affection of CHD,the lower the serum level of TBIL.

关 键 词：冠心病 胆红素 冠状动脉造影 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]