N端脑利钠肽前体对急性心肌梗死常规检查的可行性研究  

Feasibility research of NT-proBNP integrated into the routine examination of acute myocardial infarction

作　　者：李雪梅[1] 邱佩绵[1] 

机构地区：[1]广东省惠州市中心人民医院检验中心,516001

出　　处：《国际检验医学杂志》2011年第19期2194-2195,2200,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨N端脑利钠肽前体(NT-proBNP)检测在急性心肌梗死(AMI)患者诊疗中的临床价值及将其纳入AMI常规检查的可行性。方法选取84例经确诊的AMI患者,按Killip法将其分为4个心功能级别,检测NT-proBNP水平,同时检测cTnT、CK-MB,并与30例健康对照者作比较,收集临床相关资料,分析各指标间的相关性。结果 AMI患者组的NT-proBNP水平为(2 976±1 247)pg/mL,与健康对照组(104±59)pg/mL比较差异有统计学意义(P<0.01);AMI患者中的NT-proBNP与CK-MB(r=0.171,P<0.01)、cTnT(r=0.512,P<0.01)水平升高呈正相关;AMI患者中的NT-proBNP水平升高与心功能分级密切相关,各级别间差异有统计学意义。结论 NT-proBNP对急性心肌梗死患者的诊断及治疗有重要的参考价值,可作为心肌缺血标志物纳入到AMI常规检查项目中,为AMI的诊断、病情监测和预后风险判断提供客观的量化依据。Objective To investigate the changes and the diagnostic significance of NT-proBNP levels in patients with acute myocardial infarction（AMI） and the feasibility of NT-proBNP integrated into the routine examination of AMI. Methods Immunology method was applied to test NT-proBNP,cTnT and CK-MB in blood of 84 AMI patients（Killip classification： Ⅰ , Ⅱ , Ⅲ , Ⅳ ）and 30 healthy controls. The correlation between indicators based on the clinical data was analyzed. Results Whole blood NT-proBNP level in patients was（2 976--1 247）pg/mL whereas in healthy controls was （104 ± 59）pg/mL. The differences between them showed significance（P〈0.01）. NT-proBNP in patients was positively correlated with CK MB and cTnT in blood of 78 AMI patients（r= 0. 171 ,P〈0.01 ;r= 0. 512, P〈O. 01）. The whole blood level of NT proBNP was highly relative to the serious degree of cardiac function. There were significant differences of the level of blood NT proBNP between different degrees. Conclusion NT-proBNP could play an important role in AMI diagnosis and treatment. It might serve as a myocardial ischemia marker to the routine examination in order to providing objective quantitative indicator for prognosis and progress.

关 键 词：心肌梗死 N端脑钠肽前体 心肌缺血标志物 

分 类 号：R542.22[医药卫生—心血管疾病]