某地区淋球菌对6种抗生素耐药性的结果分析  

Analysis of the drug-resistance of Neisseria gonorrhoeae to 6 types of antibiotics in certain area

作　　者：曹文苓[1] 黎小东[1] 毕超[1] 梁艳华[1] 宋卫忠[1] 林路洋[1] 吴德标[1] 张莉[1] 

机构地区：[1]广州市皮肤病防治所检验科,510095

出　　处：《国际检验医学杂志》2011年第19期2205-2206,共2页International Journal of Laboratory Medicine

摘　　要：目的了解广州地区淋球菌对6种抗生素的耐药性及产青霉素酶的淋球菌(PPNG)和质粒介导的耐四环素的淋球菌(TRNG)的流行状况。方法用琼脂稀释法测定青霉素、四环素、环丙沙星、阿奇霉素、头孢曲松、大观霉素的最低抑菌浓度(MIC);用纸片碘量法检测β-内酰胺酶。结果 88株淋球菌检出PPNG 34株(38.6%)、TRNG 51株(60%)、环丙沙星耐药株87株(98.9%),同时检出PPNG、TRNG、环丙沙星高度耐药(MIC≥161 mg/L)菌株16株,占18.2%。阿奇霉素耐药株24株(27.2%),未发现头孢曲松、大观霉素的耐药菌株。结论推荐大观霉素和头孢曲松作为广州地区治疗淋病的首选药物,加强淋球菌耐药性的连续性监测十分重要。Objective To survey the antibiotic resistance and the prevalence of penicillinase-producing Neisseria gonorrhoeae （PPNG） and tetracycline resistant Neisseria gonorrhoeae （TRNG） in certain area. Methods Minimum inhibitory concentrations （MIC） to penicillin G, tetracycline, ciprofloxacin, azithromyc, ceftriaxone and spectinomycin were determined by using the agar dilution method,and β-lactamase was determined by paper iodin quantitative method. Results 34 strains （38.6%） of PPNG,51 strains （60.0%） of TRNG,87 strains （98.9%） resistant to ciprofloxacin,24 strains （27.2%） resistant to azithromyc were detected in 88 strains,while 16 strains （18.2%） were positive with penicillinase- producing, tetracycline resistant and highly resistant to ciprofloxacin（MIC≥161 mg/L）. There was no ceftriaxone or spectinomycin resistant strain. Conclusion Ceftriaxone and spectinomycin could be choice drug to treat patients with Neisseria gonorrhoeae injection and it could be important to successively survey the antibiotic resistance of Neisseriae gonorrhoeae.

关 键 词：微生物敏感性试验 淋球菌 产青霉酶的淋球菌 耐四环素的淋球菌 抗药性 

分 类 号：R446.5[医药卫生—诊断学]