平衡针对家兔肩周炎的抗炎镇痛作用研究  

Analgesic and anti-inflammatory effects of balance acupuncture on experimental scapulohumeral periarthritis in rabbits

作　　者：袁红[1] 陈榕[1] 黄大鹏[1] 王颖[1] 王文远[2] 

机构地区：[1]北京中医药大学针灸推拿学院,北京100029 [2]北京军区总医院

出　　处：《中国针灸》2011年第12期1106-1110,共5页Chinese Acupuncture & Moxibustion

基　　金：国家973重点基础研究发展计划资助项目:2007CB 512704

摘　　要：目的:探讨平衡针对肩关节周围炎的治疗作用及作用机制。方法:30只雄性新西兰家兔,随机分为空白组、模型组和平衡针组,每组10只。持续机械劳损加冰敷建立肩周炎模型,平衡针组针刺"肩痛穴",空白组与模型组不予干预。观察家兔关节活动、病变肩关节周围组织病理变化,检测血浆和肩关节周围组织白细胞介素-1β(IL-1β)、5-羟色胺(5-HT)及冈上肌腱中脱氧核糖核酸(DNA)的含量。结果:平衡针组血浆中5-HT[(18.16±4.44)ng/mL]较模型组[(23.28±5.89)ng/mL]明显降低(P<0.05),IL-1β无明显差异(P>0.05);患侧肩关节组织IL-1β、5-HT和冈上肌腱DNA平衡针组较模型组有不同程度的降低(P<0.01,P<0.05)。结论:平衡针通过减少病变肩关节组织中致痛因子、炎性因子及DNA的表达,从而减轻肩周炎模型兔的局部病变组织的机化和粘连,有效地改善肩周炎所导致的局部和全身的病理状态。Objective To investigme therapeutic effects of balance acupuncture on scapulohumeral periarthritis （SP）and the mechanisms. Methods Thirty male New Zealand rabbits were randomly divided into a blank group （group B）, a model group （group M） and a balance acupuncture group （group BA）with 10 rabbits in each group. SP model was established by using persistent mechanical strain and ice compress. Balance acupuncture at ＂Jiantang＂ point was applied in the animals in group BA, but not in the rabbits of the other two groups. Joint movement and pathological changes in tissues around the affected shoulder joint were observed,and interleukin-1β（IL-1β, 5-hydroxytryptamine （5-HT） in plasma and the affected surrounding tissues, and DNA contents in tendon of supraspinatus muscle were measured. Results The content of plasma 5-HT in group BA [（18. 16±4.44）ng/mL] wax significantly lower than that in group M [（23.28±5.89）ng/mI.]（P〈0.05）, but without obvious difference in IL-1β content between the two groups （P〉0.05）. Compared with group M, the contents of lL-1β,5-HT in affteted surrounding tissues, and DNA expression in tendon of supraspinatus muscle were significantly lowered to various extent in group BA（ P〈0. 01, P〈0.05）. Conclusion Balance acupuncture can effectively improve local and systemic pathological situation induced by SP by way of reducing pain-producing factors,inflammatory factors and DNA expression to alleviate local organization and adhesions in rabbits with experimental SP.

关 键 词：肩关节周围炎 平衡针 白细胞介素-1Β 5-羟色胺 脱氧核糖核酸 

分 类 号：R246.2[医药卫生—针灸推拿学]