Difference between CKD-EPI and MDRD equations in calculating glomerular filtration rate in patients with cirrhosis  

作　　者：Yu-Wei Chen Han-Hsiang Chen Tsang-En Wang Ching-Wei Chang Chen-Wang Chang Chih-Jen Wu 

机构地区：[1]Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan [2]Mackay Medicine, Nursing and Management College, Taipei 10449, Taiwan [3]National Taipei College of Nursing, Taipei 10449, Taiwan [4]Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan [5]Graduate Institute of Medical Science, Taipei Medical University, Taipei 11031, Taiwan

出　　处：《World Journal of Gastroenterology》2011年第40期4532-4538,共7页世界胃肠病学杂志（英文版）

摘　　要：AIM:To evaluate the difference between the performance of the (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations in cirrhotic patients. METHODS: From Jan 2004 to Oct 2008, 4127 cirrhotic patients were reviewed. Patients with incomplete data with respect to renal function were excluded; thus, a total of 3791 patients were included in the study. The glomerular filtration rate (GFR) was estimated by the 4-variable MDRD (MDRD-4), 6-variable MDRD (MDRD-6), and CKD-EPI equations.RESULTS:When serum creatinine was 0.7-6.8 mg/dL and 0.6-5.3 mg/dL in men and women, respectively, a significantly lower GFR was estimated by the MDRD-6 than by the CKD-EPI. Similar GFRs were calculated by both equations when creatinine was > 6.9 mg/dL and > 5.4 mg/dL in men and women, respectively. In predicting in-hospital mortality, estimated GFR obtained by the MDRD-6 showed better accuracy [81.72%; 95% confidence interval (CI), 0.94-0.95] than that obtained by the MDRD-4 (80.22%; 95%CI, 0.96-0.97), CKD-EPI (79.93%; 95%CI, 0.96-0.96), and creatinine (77.50%; 95%CI, 2.27-2.63). CONCLUSION: GFR calculated by the 6-variable MDRD equation may be closer to the true GFR than that calculated by the CKD-EPI equation.AIM： To evaluate the difference between the perfor- mance of the （CKD-EPI） and Modification of Diet in Renal Disease （MDRD） equations in cirrhotic patients.METHODS： From Jan 2004 to Oct 2008, 4127 cirrhotic patients were reviewed. Patients with incomplete data with respect to renal function were excluded; thus, a total of 3791 patients were included in the study. The glomerular filtration rate （GFR） was estimated by the 4-variable MDRD （MDRD-4）, 6-variable MDRD （MDRD-6）, and CKD-EPI equations.RESULTS： When serum creatinine was 0.7-6.8 mg/dL and 0.6-5.3 mg/dL in men and women, respectively, a significantly lower GFR was estimated by the MDRD-6 than by the CKD-EPI. Similar GFRs were calculated by both equations when creatinine was 〉 6.9 mg/dL and 〉 5.4 mg/dL in men and women, respectively. In predicting in-hospital mortality, estimated GFR obtained by the MDRD-6 showed better accuracy [81.72%; 95% confidence interval （CI）, 0.94-0.95] than that obtained by the MDRD-4 （80.22%; 95%CI, 0.96-0.97）, CKD-EPI （79.93%; 95%CI, 0.96-0.96）, and creatinine （77.50%; 95%CI, 2.27-2.63）.CONCLUSION： GFR calculated by the 6-variable MDRD equation may be closer to the true GFR than that calculated by the CKD-EPI equation.

关 键 词：Chronic Kidney Disease Epidemiology Col-laboration Estimated glomerular filtration rate LIVERCIRRHOSIS Modification of Diet in Renal Disease Renalfunction 

分 类 号：S858.291[农业科学—临床兽医学] F426.471[农业科学—兽医学]