Synthesis and Herbicidal Activity of Novel N-（2-Fluoro-5（3- methyl-2,6-dioxo-4-（trifluoromethyl）-2,3-dihydro-pyrimidin- l（6H）-yl）phenyl）-2-phenoxyacetamide Derivatives  

作　　者：吴道新 孙炯 黄明智 莫洪波 王晓光 李宏伟 任叶果 胡志彬 何莲 尹笃林 

机构地区：[1]School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha Hunan 410114, China [2]National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry, Changsha, Hunan 410007, China [3]Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research （Ministry of Education of China）, Hunan Normal University, Changsha, Hunan 410081, China

出　　处：《Chinese Journal of Chemistry》2011年第11期2401-2406,共6页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20872033）, Hunan Provincial Natural Science Foundation of China （No. 07JJ1003） and Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research （Ministry of Education of China） （No. KLCBTCMR2008-14）.

摘　　要：Thirteen novel N-（2-fluoro-5-（3-methyl-2,6-dioxo-4-（trifluoromethy）-2,3-dihydropyrimidin-1（6H）-yl）phenyl）- 2-phenoxy）acetamides were designed and synthesized utilizing 4-fluoro-aniline and ethyl 3-amino-4,4,4-trifluoro-but-2-enoate as starting materials. The chemical structures of all compounds were confirmed by IH NMR, IR, mass spectrum and elemental analyses. Subsequently, the herbicidal activities of the as-prepared compounds were evalu-ated in the greenhouse. Bioassay results indicated that most of compounds had better herbicidal activities against dicotyledonous weeds. Among all the tested compounds, compounds 4a--4i showed good herbicidal activities at both pre-emergence and post-emergence treatment against two or three kinds of dicotyledonous weeds, such as Abutilon theophrasti Medic, Amaranthus ascendens L, and Chenopodium album L at the dosage of 75 g ai/ha.Thirteen novel N-（2-fluoro-5-（3-methyl-2,6-dioxo-4-（trifluoromethy）-2,3-dihydropyrimidin-1（6H）-yl）phenyl）- 2-phenoxy）acetamides were designed and synthesized utilizing 4-fluoro-aniline and ethyl 3-amino-4,4,4-trifluoro-but-2-enoate as starting materials. The chemical structures of all compounds were confirmed by IH NMR, IR, mass spectrum and elemental analyses. Subsequently, the herbicidal activities of the as-prepared compounds were evalu-ated in the greenhouse. Bioassay results indicated that most of compounds had better herbicidal activities against dicotyledonous weeds. Among all the tested compounds, compounds 4a--4i showed good herbicidal activities at both pre-emergence and post-emergence treatment against two or three kinds of dicotyledonous weeds, such as Abutilon theophrasti Medic, Amaranthus ascendens L, and Chenopodium album L at the dosage of 75 g ai/ha.

关 键 词：synthesis design 2 6-dioxo-4-（trifluoromethyl）-2 3-dihydropyrimidine N-phenyl-2-phenoxyacetamide SYNTHESIS herbicidal activity 

分 类 号：TQ457.29[化学工程—农药化工] O626[理学—有机化学]