Synthesis of Pyrazolo[3,4-d]pyrimidin-4-ones Catalyzed by Brensted-acidic Ionic Liquids as Highly Efficient and Reusable Catalysts  

作　　者：Tavakoli-Hoseini, Niloofar Moloudi, Raheleh Davoodnia, Abolghasem Shaker, Mohammad 

机构地区：[1]Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran

出　　处：《Chinese Journal of Chemistry》2011年第11期2421-2426,共6页中国化学（英文版）

摘　　要：A convenient and efficient method for the synthesis of pyrazolo[3,4-d]pyrimidin-4-ones via heterocyclization reaction of 5-amino-lH-pyrazole-4-carboxamides with triethyl orthoesters using two BrCnsted-acidic ionic liquids, 3-methyl-l-（4-sulfonic acid）butylimidazolium hydrogen sulfate [MIM＋（CH2）4SO3H][ HSO4 ] or N-（4-sulfonic acid）butyl triethylammonium hydrogen sulfate [Et3N＋（CH2）4SO3H][ HSO4 ], as efficient homogeneous catalysts under solvent-free conditions is described.A convenient and efficient method for the synthesis of pyrazolo[3,4-d]pyrimidin-4-ones via heterocyclization reaction of 5-amino-lH-pyrazole-4-carboxamides with triethyl orthoesters using two BrCnsted-acidic ionic liquids, 3-methyl-l-（4-sulfonic acid）butylimidazolium hydrogen sulfate [MIM＋（CH2）4SO3H][ HSO4 ] or N-（4-sulfonic acid）butyl triethylammonium hydrogen sulfate [Et3N＋（CH2）4SO3H][ HSO4 ], as efficient homogeneous catalysts under solvent-free conditions is described.

关 键 词：homogeneous catalysis ionic liquids pyrazolo[3 4-d]pyrimidin-4-ones solvent-free condition triethyl orthoesters 

分 类 号：O643[理学—物理化学] O643.36[理学—化学]