冠心病同型半胱氨酸、脂蛋白(a)联合检测的价值  

Clinical Value of Combinative Measure the Plasma Homocysteine and Lipoprotein(a) Levels in Coronary Heart Disease

作　　者：顾秀玉 张霞[1] 张国平[1] 

机构地区：[1]苏州市立医院北区检验科,江苏省苏州市215008

出　　处：《中华全科医学》2011年第12期1951-1952,共2页Chinese Journal of General Practice

摘　　要：目的探讨血浆同型半胱氨酸(HCY)、脂蛋白(a)[LP(a)]与冠心病(CHD)发生发展的相关性。方法 CHD患者来自苏州市立医院心内科根据国际CHD诊断标准诊断的住院患者,并根据冠状动脉造影术冠脉病变支数进行分为1,2,3支血管病变组;正常对照组来自该院体检中心健康体检人员;研究对象年龄、性别匹配,具有可比性。CHD组根据冠状动脉造影术冠脉病变支数用循环酶法测定血浆HCY水平,用免疫透射比浊法测定血浆LP(a)水平。结果 CHD组HCY、LP(a)水平均值都高于正常对照组,差异有统计学意义(P<0.01)。0,1,2,3支血管病变组HCY、LP(a)浓度呈逐级增高趋势但两者增高程度有一定的差异。结论 HCY、LP(a)与冠脉粥样病变的发生、发展密切相关,是CHD的两个危险因素,如两者联合检测对冠心病的诊断和治疗预后判断具有一定的临床意义。Objective To evaluate the relationship between plasma homocysteine（HCY）,lipoprotein a and coronary heart disease（CHD）.Methods The patients were chosen from our hospital that diagnosed as CHD according to international cardiology diagnostic criteria and were divided to three groups according to coronary angiography.The control group was from the medical center health;the age and gender were matched and comparable.The levels of HCY and LP（a） were detected by automatic biochemistry analyzer.Measuring of HCY was used with cycle enzyme and LP（a） with immunoturbidimetric methods.Results The mean of item with patients was exceeded the normal control people and significant difference with statistics（P0.01）.The levels of HCY and LP（a） were a positive correlated to the severity of coronary artery disease.Conclusion The generation and development of coronary artery disease were correlated to the elevated levels of HCY and LP（a）.The value of diagnosis and treatment of coronary artery disease can be elevated by combinative measuring of HCY and LP（a）.

关 键 词：同型半胱氨酸 脂蛋白(a) 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病] R446.112.5[医药卫生—内科学]