医用生物蛋白胶在宫颈锥切手术中的应用  

Clinical application of fibrin glue in cervical conization

作　　者：李玉洁[1] 彭小萍[1] 林小玲[1] 

机构地区：[1]中山大学肿瘤防治中心华南肿瘤学国家重点实验室,510060

出　　处：《中外妇儿健康（学术版）》2011年第7期36-36,共1页

摘　　要：目的:观察医用生物蛋白胶在LEEP术后应用减少创面渗血及促进鳞状上皮修复的作用。方法:58例CIN患者行LEEP手术治疗,随机分为2组,观察组在手术后立即用生物蛋白胶喷洒于宫颈创面,对照组手术后于创面填塞明胶海绵及碘仿纱,观察两组创面渗血和鳞状上皮修复情况。结果:观察组38例使用蛋白胶4～6分钟后渗血均停止,1例于术后2天因阴道出血返院止血处理。对照组20例,术后一周内有4例需返院止血处理,两组比较差异有显著性(P<0.05)。在促进宫颈鳞状上皮化及预防腺上皮增生方面,2组比较差异无显著性(P>0.05)。结论:LEEP手术后使用生物蛋白胶,对减少宫颈创面术后渗血、封闭创面有较好的帮助。[ Objective ] ： To investigate the effects of fibrin glue （FG） in cervical loop electrosurgical excision procedure （LEEP）. [ Methods ] ： 58 cases with cervical intraepithelial neoplasia who underwent LEEP between October 2008 and April 2009 were randomly divided into two groups by applying FG on the wounds of cervix （ study group, n = 38） or vaginal packing with gelatin sponge and Iodoform gauze （ control group, n = 20） after operation. Duration of wounds bleeding and repair of squamous epithelia were recorded and compared respectively. [ Results] ： Low blood loss was observed in study group, only one case（ 1/38 ） needed hemostasis after surgery, while four cases（4/20） did in control group（ significantly different, p 〈0.05）. No significant difference in promoting repair of squamous epithelium and preventing hyperplasia of glandular epithelium between two groups. [ Conclusions] ： Application of fibrin glue can help to reduce the capillary hemorrhage and protect the wound.

关 键 词：医用生物蛋白胶 宫颈锥切术 

分 类 号：R713.4[医药卫生—妇产科学]