细胞凋亡调控蛋白bcl-2和bax在多囊卵巢综合征患者子宫内膜中的表达  

Expression of Apoptosis Regulatory Protein bcl-2 and bax in Endometrium of Polycystic Ovary Syndrome

作　　者：陈咏健[1] 王颖[1] 李美芝[1] 

机构地区：[1]北京医科大学第三医院妇产科,100083

出　　处：《中华妇产科杂志》1999年第11期652-654,I016,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的探讨多囊卵巢综合征（PCOS）患者子宫内膜中细胞凋亡调控蛋白bcl-2和bax的表达及其在PCOS患者子宫内膜病变中的意义。方法应用免疫组织化学SP方法，测定18例PCOS患者子宫内膜和27例月经周期正常、因输卵管不通或男性不育就诊的对照者子宫内膜（10例增殖期、17例分泌期）bcl-2和bax蛋白的表达。结果PCOS患者子宫内膜bcl-2表达较对照者增殖期和分泌期高（P＜0．05和P＜0．01），但bax表达相似（p＞0．05）。结论PCOS患者子宫内膜bcl-2蛋白表达增高，与bax形成更多的异源二聚体，从而抑制PCOS子宫内膜凋亡，对其子宫内膜的异常增生改变起一定作用。Objective To study the expression and implication of apoptosis regulatory protein bcl-2 and bax in endometrium of polycystic ovary syndrome (PCOS). Methods The apoptosis regulatory protein expression of bcl-2 and bax protein in endometrium were investigated by immunohistochemical method in 18 PCOS and 27 normal subjects proliferative phase 10 and secretory phase 17 Results Bcl-2 expression was higher in PCOS than tha both in control prolifrative phase(P＜ 0.05) and secotory phase (P＜ 0.001). Bax expression was not significantly different between PCOS and controls (P ＞ 0.05). Coclusions The highe bcl-2 protein expression inhibits the endometrium apoptosis and plays an important role in the abnormal proliferative changes of endometrium in PCOS.

关 键 词：多囊卵巢综合征 子宫内膜 c-bcl-2 BAX蛋白 

分 类 号：R588.602[医药卫生—内分泌]