氟-砷联合染毒对大鼠子代神经行为发育的影响  

Effect of fluoride arsenic exposure on the neurobehavioral development of rats offspring

作　　者：张晨[1] 凌冰[1] 刘继文[1] 王国荃[1] 肖碧玉[1] 

机构地区：[1]新疆医科大学公共卫生学院,乌鲁木齐830054

出　　处：《卫生研究》1999年第6期337-338,F004,共3页Journal of Hygiene Research

基　　金：国家自然科学基金

摘　　要：为揭示氟－砷共存对子代健康的影响，采用两代一窝繁殖的实验方法，测定Ｗｉｓｔａｒ大鼠暴露于氟、砷后其子代神经行为发育的情况。结果显示：随染毒剂量的增加，早期生理发育指标阳性率和早期神经反射阳性率逐渐减少，各染毒组仔鼠学习及记忆能力显著降低，游泳时间和耐缺氧时间逐渐缩短。电镜观察可见脑组织有明显病变，表现为神经细胞数量减少，核形态不规则，细胞器病变，突触数量显著减少。说明氟－砷对子代的神经系统有明显的损害作用。In order to explain the effects of fluoride arsenic exposure on the neurobehavioral development of rats, a two generations one nest reproductive test was used. Wistar rats were exposed to fluoride and arsenic for two generations. The results demonstrated that:with the increasing concentrations of fluoride and arsenic, the positive rates of early physiological development and nerve reflex were decreased obviously, and the abilities of learning and memory of the offspring were decreased, the swimming and enduring anoxia time gradually shortened. The pathological changes of brain under electron microscope were as follows:decreased number of nerve cells, irregular cell nucleus, organellae degeneration, and obvious decreased number of synapses. It was demonstrated that fluoride arsenic displayed distinct damage on the nerve system of the offspring.

关 键 词：氟-砷 子代 神经行为 发育 

分 类 号：R994.6[医药卫生—毒理学] Q593.4[医药卫生—药学]