关于注射阿莫西林舒巴坦钠用药频率研究  

The Research of Amoxicillin/sulbactam Injection Drug Use on the Frequency

作　　者：刘世亮 张辉 

机构地区：[1]山东省胶南市王台中心卫生院,山东胶南266425

出　　处：《中国医药指南》2011年第33期34-35,共2页Guide of China Medicine

摘　　要：目的研究注射用阿莫西林舒巴坦钠用药频率对疗效的影响。方法分别选取两组4～7岁儿童肺炎患儿各40名,第一组患儿根据体质量按一日75mg/kg,一日一次注射阿莫西林舒巴坦钠(2∶1),连续注射7d,第二组患儿体质量按一日75mg/kg,一日两次注射阿莫西林舒巴坦钠(2∶1),连续注射7d,比较两组患儿的康复情况。结果第一组患儿治愈率为45%,其余55%患儿中,有30%的患儿在治疗过程中出现耐药性,改用其他药物;第二组患儿治愈率为85%,5%的患儿在治疗过程中出现耐药性。结论阿莫西林为时间依赖性抗菌药物,一日两次给药,可使血药浓度维持在有效血药浓度之上,不仅提高了治愈率,还可以有效防止细菌耐药性的产生。Objective To study Amoxicillin/sulbactam injection frequency on the efficacy of medication.Methods To selected two groups of children aged 4 to 7 of the 40 children with pneumonia,the first group of children according to body weight by day 75mg/kg,once daily Amoxicillin/sulbactam injection（2：1）,continuous injection 7d,the second group of children with body mass by day 75mg/kg,twice a day Amoxicillin/sulbactam injection（2：1）,a continuous injection of 7d,compared two groups of children＇s recovery.Results The first group of children with a cure rate of 45%,the remaining 55% of the patients,30% of children in the emergence of drug resistance during treatment,use other drugs;the second group 85% cure rate in children,5% of children in the emergence of drug resistance during treatment.Conclusion Amoxicillin for the time-dependent antibiotics,administered twice a day,can serum drug concentration was maintained above the effective blood concentration,not only improve the cure rate,but also effectively prevent the emergence of bacterial resistance.

关 键 词：用药频率 临床研究 

分 类 号：R969.3[医药卫生—药理学]