深圳市男男性行为人群HIV梅毒及HCV新发感染的队列研究  

A prospective cohort study on HIV,syphilis and HCV seroconversion among men who have sex with men in Shenzhen

作　　者：赵锦[1] 蔡文德[1] 陈珠蝶[2] 刘少础[1] 张燕[1] 甘永霞[1] 陈琳[1] 程锦泉[1] 

机构地区：[1]深圳市疾病预防控制中心,广东深圳518055 [2]深圳市妇幼保健院,广东深圳518028

出　　处：《中国艾滋病性病》2011年第5期530-532,共3页Chinese Journal of Aids & STD

基　　金："十一五"重大专项课题(2009ZX10001-018);国家自然科学基金(30901224);深圳市科技计划项目(200902082)~~

摘　　要：目的了解深圳市男男性行为人群(MSM)艾滋病病毒(HIV)、梅毒及丙型肝炎病毒(HCV)抗体阳转情况。方法依托深圳市每年开展的时间场所抽样结合同伴推动抽样方法,于2009年5月招募325名MSM为前瞻性研究队列,在基线和一年随访时调查其高危行为情况,并采集血样检测HIV、梅毒和HCV抗体。结果队列随访一年,MSM队列保持率仅为56.2%,HIV血清抗体阳转率为4.44/100人年,梅毒阳转率为7.00/100人年,HCV血清抗体阳转率为1.61/100人年。结论深圳市MSM人群HIV、梅毒以及HCV的新发感染率均比较高,应考虑在现有干预方案基础上增加针对性的有效干预措施。Objective To study the incidence rate of human immunodeficiency virus（HIV）,syphilis and hepatitis C virus（HCV） seroconversion among men who have sex with men（MSM） in Shenzhen.Methods MSM were enrolled by methods of time-location sampling and respondent-driven sampling,and 325 MSM were recruited as baseline samples for a prospective cohort study.Annual follow-up visits were carried out to identify the high risk behaviors and blood samples were taken for testing the antibodies against HIV,syphilis and HCV.Results During one year follow-up,cohort retention rate was 56.2%.The incidence rate of HIV seroconversion was 4.44/100 person-years,syphilis-7.00/100 person-years,and HCV seroconversion-1.61/100 person-years.Conclusion The incidences of both HIV and syphilis as well as HCV seroconversion are comparatively high among MSM in Shenzhen.More effective measures should be implemented to reduce the infection rate in this population group.

关 键 词：男男性行为人群 艾滋病病毒 梅毒 丙型肝炎病毒 队列研究 

分 类 号：R373[医药卫生—病原生物学] R759[医药卫生—基础医学]