工人有机溶剂暴露剂量与其中毒效应的数学模型  

A Mathematic Model Related Organic Solvent Exposure with Poison Effect

作　　者：崔强[1] 

机构地区：[1]北京市疾病预防控制中心职业卫生所,100020

出　　处：《职业与健康》2011年第23期2682-2684,共3页Occupation and Health

摘　　要：目的探讨作业环境中工人吸入有机溶剂浓度与人体中毒损害程度之间是何种数学形式的定量关系。方法根据爱因斯坦著名的质能公式E=mc2,推断一种有机溶剂的现场浓度对作业工人造成健康损害的数学模型。结果吸入一定浓度的某种有机溶剂对工人造成的健康损害效应为K'=(CTWA/OEL)n。其中,指数n是显示有机溶剂毒性大小的特性值,称之为有机溶剂的生物毒性指数。某一种有机溶剂的累积致病效应(HE)=K'×接触时间(a)=(CTWA/OEL)n×接触时间(a)。结论在超出职业接触限值的环境里工作会严重损害工人健康,超标越多,损害越大。超标倍数与其健康损害效应呈指数形式变化。[Objective]To discuss what kind of mathematic model is related to organic solvent exposure concentration with toxic damage on human body in occupational environment. [Methods]According to the famous Albert Einstein＇ equation E= mc2,the derivation of a mathematic model for quantitative health damage caused by on-site concentration of an organic solvent was performed. [Results]The mathematic model for effects of health damage was K＇=（CTWA/OEL）n.n was the value of organic solvent toxicity characteristics and named as the toxicity index of organic solvent.The cumulative effect of an organic solvent was HE=（CTWA/OEL）n×duration（a）. [Conclusion]When the organic solvent concentration is higher than the Occupational exposure limit（OEL）,the toxic damage on health is severe.The increasing OEL exceeding times can make more serious harm to the worker and the effect factor is in exponential function form.

关 键 词：数学模型 有机溶剂浓度 健康损害效应 

分 类 号：R135[医药卫生—劳动卫生]