急性心肌梗死患者血脂和高敏C反应蛋白变化的临床意义  

Clinical significance of changes in levels of blood lipid and hs-CRP in patients with acute myocardial infarction

作　　者：阮坚丽[1] 鲍逸民[1] 杨永青[2] 

机构地区：[1]南京医科大学附属苏州市立医院急诊科,215002 [2]南京医科大学附属苏州市立医院核医学科,215002

出　　处：《中华老年心脑血管病杂志》2011年第12期1090-1092,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨急性心肌梗死(AMI)患者血脂和高敏C反应蛋白(hs-CRP)变化的临床意义。方法选择158例AMI患者为AMI组,60例健康体检者为对照组,均测定血脂和hs-CRP水平,并将存活的96例和死亡的37例患者治疗前后血脂和hs-CRP进行分析。结果与对照组比较,AMI组hs-CRP明显升高(P<0.01),TC、TG和LDL-C明显降低(P<0.05),HDL-C虽降低,但差异无统计学意义(P>0.05)。与治疗前比较,治疗后存活患者hs-CRP明显降低(P<0.05),TC、TG、HDL-C和LDL-C升高(P<0.05);而死亡患者hs-CRP明显升高(P<0.01),TC、TG、HDL-C和LDL-C明显降低(P<0.05)。存活者与死亡者血脂和hs-CRP比较,差异有统计学意义(P<0.05,P<0.01)。结论 AMI患者血脂和hs-CRP早期即出现异常改变,其持续性改变与病情变化相关,并有利于观察治疗和判断预后。Objective In order to study the clinical significance of changes of levels of blood lipid and hs-CRP for the therapy and prognosis of acute myocardial infarction（AMI）. Methods The blood lipid（TC,TG,HDL-C and LDL-C） and hs-CRP levels were measured in 158 patients with AMI and 60 controls. Results Serum hs-CRP levels in 158 patients with AMI were significantly higher than those in 60 controls（P〈0.01）. In blood lipid,serum TC,TG and LDL-C levels in 158 patients with AMI were significantly lower than those in 60 controls （ P〈0. 05 ） , but serum HDL-C was a little lower. Serum hs-CRP levels after therapy in 96 survived patients with AMI were significantly lower than those before therapy（P〈2.0.05）,but in 37 died patients with AMI were significantly increased（P〈0.01）. Serum TC, TG, HDL-C and LDL-C levels after therapy in 96 survived patients were significantly higher than those before therapy（P〈0.05） and covered to normal levels, but in 37 died patients were continually decreased and significantly lower（P〈0.05）. Conclusion The blood lipid and hs CRP were abnormal in early perid of AMI patients. It was concluded that the continual changes were related disease condition, but observation therapy and predicts prognosis.

关 键 词：心肌梗死 血脂异常 C反应蛋白质 动脉粥样硬化 危险因素 

分 类 号：R542.22[医药卫生—心血管疾病]