罗哌卡因含或不含肾上腺素硬膜外麻醉的药效学和药代动力学  

Pharmacodynamics and pharmacokinetics of ropivacaine given with or without epinephrine for epidural blockade

作　　者：涂恩平[1] 吴新民[1] 解大建[1] 胡晓华 

机构地区：[1]北京医科大学第一医院麻醉科,100034

出　　处：《中华麻醉学杂志》1999年第12期714-716,共3页Chinese Journal of Anesthesiology

摘　　要：目的 观察肾上腺素对１％罗哌卡因硬膜外阻滞的药效学和药动学影响。方法 选择ＡＳＡＩ～Ⅱ级行下腹部手术病人１６例，随机分为两组。每组８例。分别用１％罗哌卡因２ｍｇ·ｋｇ＾－１（Ｒ组）和加入１：２０００００肾上腺素的１％罗哌卡因２ｍｇ·ｋｇ＾－１（ＲＥ组）行硬膜外阻滞，对比两组药效学和药代动力学指标，结果 两组药效学指标，Ｃｍａｘ和ＡＵＣ间均无显著性差异。与Ｒ组相比，ＲＥ组的Ｔｍａｘ明显后延（Ｐ〈０．Objective To determine the pharmacokinetics and pharmacodynamics of ropivacaine used with or without epinephrine for epidural blockade. Methods Sixteen ASA physical status Ⅰ or Ⅱ adult patients undergoing elective lower abdominal surgery, were randomly divided into two groups, in group R (n=8) epidural blockade was induced with 1% ropivacaine 2mg. kg-1 without epinephrine, while in group RE (n=8) with 1% ropivacaine Zing· kg-1 with 1: 200 000 epinephrine. The onset time, the duration of analgesia and motor blockade degree of both groups were observed and plasma concentrations of ropivacaine of both groups were measured with gas chromatography. Results There were no significant differences in pharmacodynamic parameters, peak plasma concentration and area under the plasma concentration-time curve between both groups. The time to peak plasma concentration in group RE was longer than that in group R (P<0. 01). The elimination rate constant of group RE was lower than that of group R (P<0.05). Conclusion Addition of epinephrine can not affect the pharmacodynamics of epidural 1% ropivacaine, but the absorption and elimination rates of which is reduced.

关 键 词：药代动力学 硬膜外麻醉 罗哌卡因 药效学 

分 类 号：R971.2[医药卫生—药品] R969.1[医药卫生—药学]