中药单体组合的血管舒张作用研究  

Study on the vasodilator effect of components combination of Chinese materia medica

作　　者：刘蓉[1] 卞筱泓[1] 许激扬[1] 聂煜[1] 巫龙[1] 

机构地区：[1]中国药科大学生化教研室,江苏南京210009

出　　处：《华西药学杂志》2011年第6期551-553,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金项目(批准号:81073010)

摘　　要：目的比较钩藤碱、葛根素、天麻素、黄芩苷单体及组合物对血管的舒张作用,为中药组分结合研究提供实验依据。方法以大鼠胸主动脉为对象,分别考察钩藤碱、葛根素、天麻素、黄芩苷单体和组合物对去甲肾上腺素预收缩血管的舒张作用。结果 6种组合物中,天麻素和葛根素的比例为1∶1时血管舒张效果最强。结论组分结合后,舒血管效果较单体有了明显提高,提示组分结合理论研究具有一定的意义。OBJECTIVE To contrast the vasodilator effect of rhynchophylline,puerarin,gastrodin,baicalin and their combinations and supply experiment basis for Chinese materia medica components combination study.METHODS Using the chest artery of SD rat as a specimen,the relaxations of each component and their combinations at different concentration levels on blood vessel precontracted by NE were contrasted.RESULTS When the ratio between puerarin and gastrodin was one to one,the relaxation was the biggest in the six combinations.CONCLUSION The relaxations of the combinations were apparently bigger than each components.It indicated that the theory study of components combination was significant.

关 键 词：降血压 有效成分组合 组分中药 舒血管 

分 类 号：R96[医药卫生—药理学]