PEG-grafted PVA Membrane and Its Blood Compatibility  

作　　者：JIN Gu YAO Qi-zhi DONG Li-quan MA Feng 

机构地区：[1]Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China

出　　处：《Chemical Research in Chinese Universities》2011年第6期1078-1082,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.29405038)

摘　　要：Preparation and blood compatibility of different shape polyvinyl alcohol（PVA） membrane were investigated. Firstly, the tabular and tubular[polytetrafluoroethylene（PTFE） capillary as supporter] PVA membranes were prepared; then, methoxy polyethylene glycol（mPEG） was grafted onto the surface of the PVA membranes. The effects of the shape, structure and properties of the membrane surface on blood compatibility were studied in detail. The experiment results show that mPEG modified PVA membranes, especially mPEG modified tubular membrane, could availably repel the adhesion of the platelets. In addition, the anticoagulant mechanism of mPEG with a steric repulsion effectiveness was confirmed further via different grafting methods.Preparation and blood compatibility of different shape polyvinyl alcohol（PVA） membrane were investigated. Firstly, the tabular and tubular[polytetrafluoroethylene（PTFE） capillary as supporter] PVA membranes were prepared; then, methoxy polyethylene glycol（mPEG） was grafted onto the surface of the PVA membranes. The effects of the shape, structure and properties of the membrane surface on blood compatibility were studied in detail. The experiment results show that mPEG modified PVA membranes, especially mPEG modified tubular membrane, could availably repel the adhesion of the platelets. In addition, the anticoagulant mechanism of mPEG with a steric repulsion effectiveness was confirmed further via different grafting methods.

关 键 词：Polyvinyl alcohol（PVA） Polyethylene glycol（PEG） MEMBRANE PLATELET ADHESION 

分 类 号：TQ328.8[化学工程—合成树脂塑料工业] O623.413[理学—有机化学]