杂交瘤细胞核糖核酸抗病毒作用  

Effect of anti-virus of RNA from hybridoma cell

作　　者：张涛[1] 封江南[1] 

机构地区：[1]卫生部武汉生物制品研究所免疫研究室,武汉430060

出　　处：《中国免疫学杂志》1999年第12期542-544,共3页Chinese Journal of Immunology

摘　　要：目的：从分泌抗狂犬病毒糖蛋白单克隆抗体（ＩｇＭ）杂交瘤细胞中提取核糖核酸，研究其抗狂犬病毒的作用。方法：腹腔注射该种核糖核酸４ｗ后用狂犬病毒ＣＶＳ株进行颅腔攻击。结果：该核糖核酸能明显延长动物的生存时间。结论：该核糖核酸对狂犬病毒且有一定的抵抗作用。Objective: TO Study the possibility of RNA extracted from hybridoma cell as RNA and the relation between this RNA and tranditional RNA. Methods: Extracting RNA from the hybridoma cell which secrets monoclonal antibody(IgM)against the G-Protein of Tabies virusand injecting these RNA into cranial cavity in four weeks.Results: The RNA eextracted from hybridoma cell could delay the dying of force Obviously. Conclusion: The RNA extracted from hybridoma cell had the same function as the traditional immune RNA,wihch could Provided a newnethod to study the mechanism of immune RNA.

关 键 词：免疫核糖核酸 杂交瘤 单克隆抗体 狂犬病毒 

分 类 号：R392.11[医药卫生—免疫学]