脑血宁口服液对大鼠局灶性脑缺血的保护作用  

Protective effects of Naoxuening oral liquid on focal cerebral ischemia in rats

作　　者：贾士奇[1] 王军[1] 王玉升[1] 周红艳[1] 郭湘云[1] 

机构地区：[1]河南省中医药研究院,郑州450004

出　　处：《中国药学杂志》1999年第12期809-811,共3页Chinese Pharmaceutical Journal

摘　　要：目的：研究脑血宁口服液对大鼠局灶性脑缺血损伤的保护作用。方法：通过阻断大鼠一侧大脑中动脉（ ＭＣＡ） 造成局灶性脑缺血模型（ＭＣＡＯ），观察脑血宁口服液对神经病学症状、被动性条件反射、脑梗死面积及脑组织病理组织学的影响。结果：脑血宁口服液可显著改善模型大鼠神经病学症状，缩小梗塞面积，促进坏死灶内血管和胶质细胞增生修复，减少脑组织水肿和炎性细胞浸润。结论：脑血宁口服液对大鼠局灶性脑缺血具有明显的防治作用。OBJECTIVE: To study the protective effects of naoxuening oral liquid (NXN) on focal cerebral ischemia in rats METHOD: Focal cerebral ischemia was produced in rats by occluding the middle cerebral artery (MCA) on one side The therapeutic effects of NXN (made of radix astragli, radix angeicae sinensis, rhizoma chuanxiong, flos carthami, radix rehmanniae, scorpio, radix puerariae, etc ) were studied by investigating neurological outcome, passive conditional reflex, infarct size of the brain and pathology of brain tissue RESULTS: NXN could not only improve obviously nervous symptoms but also lessen the infarct size, promote proliferation and repair of the neogenetic capillary and gliocytes in the malactic and necrotic regions and reduce edema and inflammatory reaction around the necrotic region CONCLUSION: NXN showed obvious protective effects on focal cerebral ischemia in rats

关 键 词：脑血宁口服液 局灶性脑缺血 药理 中药 

分 类 号：R277.733.4[医药卫生—中医学]