开博通对兔缺血再灌注损伤心肌的保护作用  

The protective effects of captopril on myocardial ischemic reperfusion injury

作　　者：张志坚[1] 高晓东[1] 高岭 黄幼田[1] 金寒[1] 汤宁[1] 

机构地区：[1]河南医科大学病理生理学教研室,郑州4500522 [2]河南省电力医院,郑州450052

出　　处：《河南医科大学学报》1999年第4期25-28,共4页Journal of Henan Medical University

摘　　要：目的：在兔急性心肌缺血再灌注损伤模型上观察开博通对再灌注损伤心肌的影响。方法：２０ 只大耳白兔随机分为２ 组，Ⅰ组（对照组，ｎ＝１０） ，心肌缺血４５ ｍｉｎ，再灌注１８０ ｍｉｎ，未给治疗；Ⅱ组（开博通组，ｎ ＝ １０） ，心肌缺血２０ ｍｉｎ 时从左股静脉注入开博通８－８ ｍｇ／ｋｇ，２ ｍｉｎ 后继以每ｈ ８．８ ｍｇ／ｋｇ，药量持续至实验结束，总缺血时间不变，分别观察２ 组的心功能变化，心肌梗死范围变化，再灌注期间心律失常的发生率，缺血区心肌ＳＯＤ 活性变化。结果：①心功能改变：再灌后，Ⅰ组各项心功能指标进行性恶化（ Ｐ＜ ０－０５） ，Ⅱ组有不同程度恢复，尤其是心室收缩功能恢复更为明显；②心肌梗死范围变化：Ⅰ组左室梗死／ 缺血面积为４９－７２ ％ ，Ⅱ组为３２－２４ ％ ，２ 组相比差异有显著性（ Ｐ＜０－０５），２ 组间缺血面积无显著差异；③再灌注１８０ ｍｉｎ 期间，Ⅰ组室性早搏（ＶＢＰ），室性心动过速（ＶＴ） ，心室纤颤（ＶＦ） 发生率分别为９０％ ，４０％ ，４０％ ，Ⅱ组ＶＢＰ，ＶＴ，ＶＦ发生率分别为４０％ ，１０％ ，１０％ ，与Ⅰ组相比均有所降低（ Ｐ＜０－０５）；④ＳＯＤ 活性变化：２ 组缺血区ＳＯＤ 活性较非缺血区明显降?Aim:To study the effects of captopril on acute myocardial ischemic reperfusion injury.Methods:Twenty rabbits were divided at random into two groups.GroupⅠ(model Group, n =10),mycardial ischemia for 45 min,reperfusion for 180 min,no treatment;Group Ⅱ(captopril Group, n =10),myocardial ischemia for 20 min,inject captopril at the rate of 8.8 mg/kg into left femoral vein,for 2 min,the drip captopril at the rate of 8.8 mg/kg Per hour until the end of the experiment.Results:①Cardial function change:after reperfusion,all cardial function parameters in Group Ⅰ got worse and worse( P <0 05),but p LVS 、+ dp/dt (max)recovered fast in Group Ⅱ;②campared with Group Ⅰ,the percentage of the size of cardiac infarction was smaller in Group Ⅱ( P <0 05);③during 180 minutes reperfusion,the incidence of ventricular premature beats,ventricular tachycardia and ventricular fibrillation in Group Ⅱ was lower than that in Group Ⅰ( P <0 05);④compared with Group Ⅰ,SOD activity raised obviously in ischemic area of Group Ⅱ( P <0 05) Conclusion:①Captopril can improve the function of reperfusion injury;②captopril can drop the incidence rate of arrhythmia.

关 键 词：心肌缺血 再灌注损伤 开博通 心功能 

分 类 号：R542.2[医药卫生—心血管疾病]