脑胶质瘤的瘤组织间液放疗临床研究  

Tumor interstitial fluid brachytherapy for cerebral glioma

作　　者：李安民[1] 傅相平[2] 张志文[2] 薛菁晖[2] 赵明[2] 郭晓明[2] 闫润民[2] 易林华[2] 

机构地区：[1]解放军总医院海南分院神经外科,海南三亚572013 [2]解放军总医院第一附属医院神经外科,北京100048

出　　处：《军医进修学院学报》2011年第12期1198-1200,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：国家自然科学基金项目(30772245;39270668)

摘　　要：目的探讨脑胶质瘤的瘤组织间液放疗新技术的临床应用。方法总结2006年1月-2008年5月,17例接受瘤组织间液放疗患者的临床资料。结果临床疗效依据WHO判定实体瘤的疗效评定,治疗后中位生存期达22个月,17例中CR5例(29.4%),PR 7例(41.2%),SD 3例(17.6%),PD 2例(11.8%)。2年生存率52.9%,3年生存率47.0%。17例中5例影像学治愈。常见并发症是甲状腺损害后功能低下。结论利用瘤组织间液特性,采取立体定向技术,应用改良的Ommaya囊将液态131I核素恒速微量泵入瘤体内,在瘤区组织间液的更新过程中,对瘤细胞进行近距离放疗,获得良好临床疗效。Objective To study the clinical application of tumor interstitial fluid rachytherapy（TIFB） in treatment of cerebral glioma. Methods Clinical data about 17 glioma patients treated with TIFB from January 2006 to May 2008 were summarized. Results Clinical outcomes of the patients were assessed according to the WHO solid tumor scales. The mean survival time of the 17 patients was 22 months after treatment. CR, PR, SD and PD were found in 5 （29.4%）, 7 （41.2%）, 3 （17.6%） and 2 （11.8%） out of them, respectively. The 2- and 3-year survival rate for them was 52.9% and 47.0%, respectively. Radiology showed that 5 out of the 17 patients were completely cured. The common complication was hypothyroidism. Conclusion TIFB for tumor cells can achieve a rather good clinical outcome of glioma by pumping a micro- volume of liquid ^131I into it at a fixed speed through the modified Ommaya reservior using the stereo-directional technique during the refreshing of tumor interstitial fluid.

关 键 词：恶性脑胶质瘤 间质近距离放疗 液态核素 

分 类 号：R651.11[医药卫生—外科学]