结构脂肪乳剂在高胆红素血症患者中应用的安全性研究  

Safety of structured triglyceride used in treatment of hyperbilirubinemia patients:A comparative study

作　　者：康红军[1] 宋青[1] 周飞虎[1] 

机构地区：[1]解放军总医院重症医学科,北京100853

出　　处：《军医进修学院学报》2011年第12期1235-1236,1244,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：解放军总医院科技创新苗圃基金(11KMZ04)

摘　　要：目的比较结构脂肪乳剂(STG)和物理混合的中/长链脂肪乳剂(MCT/LCT)在高胆红素血症患者中应用的安全性。方法回顾性分析2008年-2009年25对高胆红素血症(术后当天血清总胆红素200-400μ mol/L)术后肠外营养应用脂肪乳≥5d的患者,STG组25例,MCT/LCT组25例。结果与使用脂肪乳前比较,两组使用脂肪乳后第1天和第5天谷丙转氨酶(ALT),谷草转氨酶(AST),碱性磷酸酶(AKP),γ-GT及胆红素均有所下降(P<0.05),甘油三酯无明显变化(P>0.05)。两组患者使用后第1天和第5天血生化指标无明显差异(P>0.05)。结论结构脂肪乳剂在高胆红素血症患者中应用对肝功能的影响与物理混合MCT/LCT无明显差异。Objective To compare the safety of structured triglyceride（STG） and physically mixed medium chain triglyceride/long chain triglyceride（MCT/LCT） used in treatment of hyperbilirubinemia patients.Methods Fifty hyperbilirubinemia patients admitted to our hospital from 2008 to 2009 with a serum total bilirubin of 200-400μmol/L on the postoperative day were divided into STG group（n=25） and MCT/LCT group（n=5）.Their parenteral STB and MCT/LCT nutrition in patients for≥5 days was retrospectively analyzed.Results The ALT,AST,AKP,γ-GT and bilirubin levels were significantly lower in the two groups 1 and 5 days after the STG and MCT/LCT were used than before they were used（P〈0.05）.However,no significant difference was found in triglyceride between the two groups（P〉0.05）.Conclusion The effects of STG and MCT/LCT are not significantly different on the liver function of hyperbilirubinemic patients.

关 键 词：结构脂肪乳剂 高胆红素血症 物理混合中/长链脂肪乳剂 

分 类 号：R459.3[医药卫生—治疗学]