黄芪丹参对急性肺损伤模型大鼠的防治作用  

Role of astragalus mongholicus and salvia miltiorrhiza for supplementing Qi and activating blood circulation in prevention and treatment of rat acute lung injury

作　　者：杨明会[1] 张海燕[1] 王文明[2] 刘毅[1] 李绍旦[1] 

机构地区：[1]解放军总医院中医研究所,北京100853 [2]北京中医药大学,北京100029

出　　处：《军医进修学院学报》2011年第12期1257-1259,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：国家自然科学基金项目(30873344)~~

摘　　要：目的探讨益气活血中药黄芪与丹参对急性肺损伤的防治作用。方法 48只SD雄性大鼠随机分为正常对照组、模型对照组、中药组各16只,模型对照组和正常对照组每日予以0.9%氯化钠注射液2ml灌胃,连续1周,中药组每日予以中药液(0.25g/ml)2ml灌胃,连续1周,模型对照组、中药组动物造模采用LPS气管滴入法,正常对照组按同样方法气管滴入同等体积0.9%氯化钠注射液,监测大鼠肺系数、肺通透指数、动脉血气变化,观察肺组织病理形态学改变。结果中药组大鼠肺系数值4.24±0.37、肺通透指数(0.88±0.20)%、肺泡损伤数比值(17.7±6.1)%均明显低于模型对照组(P<0.01);中药组大鼠的PaO2(98.83±2.74)mmHg(1mmHg=0.133kPa)、SaO2(96.76±1.19)%均明显高于模型对照组(P<0.01);中药组各项指标与正常对照组比较均无显著性差异(P>0.05);正常对照组和中药组大鼠肺组织结构清晰,模型对照组大鼠肺组织明显受损。结论益气活血中药黄芪和丹参对ALI具有明显的防治作用。Objective To study the role of Chinese herbal medicines（astragalus mongholicus and salvia miltiorrhiza）for supplementing Qi and activating blood circulation in prevention and treatment of acute lung injury（ALI）.Methods Forty-eight male Sprague Dawley rats were randomly divided into normal control group,model control group,and Chinese herbal medicine group（16 in group）.Animals in model control group and normal control group received intra-gastric 2ml normal saline（NS） daily for a week,those in herbal medicine group received intra-gastric 2ml herbal medicine liquid（0.25g/ml） daily for 1 week.ALI models were established by intra-tracheal lipopolysacchride（LPS） drip for model control group and Chinese herbal medicine group,and by intra-tracheal NS drip for normal control group.Lung index（LI）,lung permeation index（LPI）,and index of quantitative assessment（IQA） were monitored,and morphological changes in the lungs were observed.Results The LI（4.24±0.37）,LPI（0.88%±0.20%）,and IQA（17.7%±6.1%） were significantly lower while the PaO2（98.83±2.74mmHg） and SaO2（96.76 %±1.19%） were significantly higher in Chinese herbal medicine group than those in model control group（P〈0.01）.However,no significant difference was observed in the lung structure between Chinese herbal medicine group and normal control group（P〉0.05）.Conclusion Astragalus mongholicus and salvia miltiorrhiza play a significant role in prevention and treatment of ALI.

关 键 词：急性肺损伤 益气活血中药 黄芪 丹参 防治作用 

分 类 号：R285[医药卫生—中药学]