热敏灸对抑郁症模型大鼠行为学的影响  

Effect of Heat-sensitive Moxibustion on Behavioral Results in Depression Model Rats

作　　者：肖爱娇[1] 康明非[2] 陈日新[2] 肖东北 曹丹 

机构地区：[1]江西中医学院生理学教研室,南昌330004 [2]江西中医学院附属医院针灸康复科,南昌330006 [3]江西中医学院,2007级生物工程班南昌330006

出　　处：《江西中医学院学报》2011年第4期24-28,共5页Journal of Jiangxi College of Traditional Chinese Medicine

基　　金：江西省教育厅科技项目(GJJ10558);江西省卫生厅中医药科研项目(2009A006);江西中医学院科研课题(JZ0911)

摘　　要：目的:制备抑郁症大鼠模型,观察热敏灸"百会"对抑郁症大鼠模型行为学结果的影响,了解热敏灸"百会"治疗抑郁症的效果。方法:用雌性SD大鼠,采用孤养和慢性不可预见性温和应激(CUMS)制备抑郁症大鼠模型。以Open-Field测试大鼠的直立活动和水平活动得分;以1h内大鼠摄入饮用水和蔗糖水量计算糖水消耗百分比;以Morris水迷宫测试大鼠的学习记忆力。结果:与模型组相比,热敏灸组大鼠的水平活动得分和直立活动得分均增加;糖水消耗百分比升高;逃避潜伏期缩短。结论:热敏灸"百会"具有改善抑郁症的效果。Objective： To observe the effect of heat-sensitive moxibustion on behavioral results in depression model rats.Methods： Female SD rats are induced into depression model by giving alone in combination with 21 days of chronic unexpected mild stress.Open-Field was used to test crossing and rearing,Sucrose consumption test was used to calculate the percentage of sucrose intake,Morris water maze was employed to evaluate learning and memory abilities.Results： Compared to rats in the model group,rats in the heat-sensitive moxibustion group showed that both crossing scores and rearing scores were increased,the percentage of sucrose intake was risen and the escape period was shorten.Conclusion： Heat-sensitive moxibustion has improved the symptoms of depression.

关 键 词：热敏灸 抑郁症 慢性不可预见性温和应激 

分 类 号：R241.81[医药卫生—中医诊断学]