白藜芦醇烟酸酯抗炎、降脂和保肝药理作用研究  

Studies on the Anti-inflammatory、Antihyper Lipidemia、Protecting Liver Activities of Resveratrol Trinicotinate

作　　者：黄鹏[1] 栗进才[1] 汪电雷[1] 尹登科[1] 张瑞[1] 

机构地区：[1]安徽中医学院药学院安徽省现代中药重点实验室,合肥230038

出　　处：《江西中医学院学报》2011年第4期64-67,共4页Journal of Jiangxi College of Traditional Chinese Medicine

摘　　要：目的:通过对经白藜芦醇和烟酸进行酯化合成的白藜芦醇烟酸酯进行抗炎、降脂、保肝作用的筛选,为其进一步研究与开发提供实验依据。方法:采用二甲苯致小鼠耳肿胀法、10%蛋清诱导大鼠足肿胀模型,观察白藜芦醇烟酸酯的抗炎作用;采用小鼠腹腔注射75%蛋黄乳液建立高血脂模型,观察白藜芦醇烟酸酯的降血脂作用。采用小鼠腹腔注射0.1%CCl4造成急性肝损伤模型考察白藜芦醇烟酸酯保肝方面的药理活性。结果:白藜芦醇烟酸酯能显著抑制二甲苯所致的小鼠耳肿胀,减少蛋清所致大鼠足肿胀的形成,并可显著降低高血脂动物模型血清中TG、TC浓度,但对0.1%CCl4造成急性肝损伤血清中ALT、AST升高无明显影响。结论:白藜芦醇烟酸酯在抗炎、降脂方面表现出一定的生物活性,本实验结果可为进一步进行白藜芦醇烟酸酯研究提供了实验依据。Objective： To study anti-inflammatory,anti-hyperlipidemia,hepatoprotective effects of resveratrol trinicotinate by esterification synthesis of resveratrol and niacin,and provide experimental basis for further research and development.Methods： The methods of xylene-induced ear edema in mice and edema of rat hind paw induced by egg albumin in rats were used to observe the anti-inflammatory effects of resveratrol trinicotinate;The methods of hyperlipemia model by ip injection 75% yolk emulsion in rats were used to observe the reducing blood lipid;The Acute liver injury model was established by 0.1% CCl4 in mice to observe the hepatoprotective effect of resveratrol trinicotinate.Results： Resveratrol nicotinate could inhibit xylene-induced ear edema and decrease on edema of rat hind paw.,and reduce TG,TC of hyperlipemia model,but could not influce ALT、AST in Serum.Conclusion： Resveratrol tirnicotinate has significant biological activity in anti-inflammatory effects and reducing blood lipid,to supply the experimental basis for further research of resveratrol trinicotinate.

关 键 词：白藜芦醇烟酸酯 白藜芦醇 抗炎 降脂 保肝 

分 类 号：R927.2[医药卫生—药学]