土茯苓对高尿酸症小鼠肾损伤的防治作用  

Preventive and Therapeutic Effects of Glabrous Greenbrier Rhizome on Hyperuricemic and Renal Injury in Rats

作　　者：郭淑云[1] 张薇[2] 张琰[1] 刘梅[1] 刘玲娜[1] 杜小燕[1] 

机构地区：[1]第四军医大学唐都医院药剂科,陕西西安710038 [2]第四军医大学唐都医院儿科,陕西西安710038

出　　处：《现代生物医学进展》2011年第23期4427-4429,共3页Progress in Modern Biomedicine

摘　　要：目的:观察土茯苓对高尿酸症小鼠肾功及血清尿酸的影响。方法:将昆明种小鼠分为正常对照组、模型对照组、土茯苓治疗组、别嘌呤醇治疗组,造模成功后分别给予土茯苓、别嘌呤醇灌胃,7d后检测各组大鼠血中肌酐(Cr),尿素氮(Bun)、尿酸(UA)及黄嘌呤氧化酶(XOD)。结果:治疗7d后,与模型组相比,土茯苓治疗组大鼠血肌酐、尿素氮、血UA、XOD明显降低(P<0.0 5)。结论:土茯苓对高尿酸症小鼠肾功能有保护作用,对尿酸升高有明显的治疗作用。Objective： To investigate the Glabrous Greenbrier Rhizome（GGR） effect on the kidney function and serum uric acid of rats with hyperuricosuria. Methods： The Kunming rats were divide into normal group, model group, and treatment groups with Glabrous Greenbrier Rhizome, as well as treatment group with dose of Allopurinol. After the models were built successfully, the rats were perfused with Glabrous Greenbrier Rhizome and allopurinol. 7 days later, the level of Cr, Bun, UA and XOD of the rats in different groups was. Results： After 7 days＇ treatment, the level of Cr, Bun, blood UA and XOD drops remarkably in the rats of the treatment groups with Glabrous Greenbrier Rhizome （P〈0.05） compared with that in the model group. Conclusion： Glabrous Greenbrier Rhizome has protective effect on the kidney function of rat with hyperuricosuria and it also has therapeutic effect on elevated uric acid.

关 键 词：茯苓 高尿酸症 肾损伤 黄嘌呤氧化酶(XOD) 

分 类 号：Q95-3[生物学—动物学] R285[医药卫生—中药学]