诱导小鼠产生脑缺血耐受的时间窗探讨  

作　　者：王朝辉[1] 颜国华 马霄 苗明三[3] 

机构地区：[1]河南省中医药研究院,河南郑州450008 [2]郑州澍青医学高等专科学校,河南郑州450064 [3]河南中医学院,河南郑州450008

出　　处：《黑龙江科技信息》2011年第34期80-80,250,共2页Heilongjiang Science and Technology Information

基　　金：河南省重大公益性科研计划[豫财办教(2007)264号]

摘　　要：目的:探讨诱导小鼠产生脑缺血耐受的时间窗。方法:采用两次结扎小鼠双侧颈总动脉方法造脑缺血耐受模型,通过观察不同预处理诱导时间窗下小鼠脑组织形态的变化,探讨诱导小鼠脑缺血耐受产生的最佳时间窗。结果48h、168h、240h诱导组、缺血再灌注组小鼠脑神经细胞病理改变明显加重,120h诱导组脑缺血耐受较其他实验组好。结论:120h诱导时间窗为比较合适的脑缺血耐受时间。Ohjecdve Discuss the time window which induces the brain ischemic tolerance of mice .Methods Use the method of fling up the two-sided arteria carotis communis anterior of mice twice to make the model of brain ischemic tolerance,through observing the changes of brain tectology of mice under the different time window which induces the brain ischemic tolerance, to establish the optimal inducing time window. Results The pathological changes in brain tissue is significantly increased of 48hours,168 hours,240 hours time window groups which induce the brain ischemic tolerance and ischemia-reperfusion group,compared with other experimental groups,the time window which induces the brain ischemic tolerance of 120 hours group can remarkably enhance the tolerance function of nerve cell when the blood lacks of brain.Conclusion 120 hours are the suitable induction time window of mice brain ischemic tolerance.

关 键 词：脑缺血耐受 双侧颈总动脉 诱导时间窗 缺血再灌注 

分 类 号：Q426[生物学—神经生物学]