含纳米银的抗菌水凝胶研究  

Silver Nanoparticles-based Antibacterial Hydrogels

作　　者：杨立群[1] 林凯城[1] 沈荣春[1] 马林[1] 张黎明[1] 卢亢 

机构地区：[1]中山大学化学与化学工程学院//聚合物复合材料及功能材料教育部重点实验室//新型聚合物材料设计合成与应用广东省高校重点实验室,广东广州510275 [2]广东泰宝科技医疗用品有限公司,广东普宁515300

出　　处：《中山大学学报（自然科学版）》2011年第6期58-61,共4页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：国家自然科学基金资助项目(20974130);教育部高校基本科研业务费中山大学青年教师培育资助项目(09lgpy14);广东省部产学研结合资助项目(2009B090300122)

摘　　要：为赋予水凝胶的抗菌性能,该文对含有纳米银的水凝胶进行了研究。首先在硝酸银溶液加入硼氢化钠还原剂和聚乙烯砒咯烷酮分散剂,合成纳米银;然后将不同体积的纳米银分散液加入到卡波姆溶液中,搅拌下滴加氢氧化钠溶液,制备含纳米银的水凝胶。紫外-可见光谱法的结果表明硝酸银被还原成纳米银,X-射线粉末衍射法证实纳米银被分散在水凝胶中,并通过Scherrer公式计算出纳米银的尺寸约为5 nm。溶胀性能测试结果表明水凝胶的溶胀率约为900%。抑菌性能测试结果显示,当水凝胶中纳米银浓度为10μg/mL(低于纳米银的安全浓度25μg/mL),水凝胶能有效抑制大肠杆菌和金黄色葡萄球菌的生长。所制备的抗菌水凝胶可望应用于创伤皮肤和皮肤疾病的外用治疗。The silver nanoparticles-based hydrogels were investigated in order to increase the antibacterial property in this work.The silver nanoparticles were synthesized in aqueous silver nitrate solution by adding sodium borohydride as a reduction reagent and polyvinyl pyrrolidone as a dispersion aid.And then the silver nanoparticles-based hydrogels were further prepared in the carbomer solution by adding the dispersion solutions of silver nanoparticles with different volumes and sodium hydroxide solution.The result of UV-vis analysis indicated that the silver nanoparticles were successfully synthesized.The existence of silver nanoparticles in the hydrogels was confirmed by X-ray scattering analysis,and the diameters of silver nanoparticles were calculated to be about 5 nm according to the Scherrer equation.The swelling ratio of the hydrogels was determined to be 900%.The hydrogels exhibited strong antibacterial properties to Escherichia coli and Staphylococcus aureus with the content of silver nanoparticles 10 μg/mL,which is lower than the safe content of silver nanoparticles 25 μg/mL.The hydrogels are thus anticipated to be used for the treatment of wounded skin and skin disease.

关 键 词：水凝胶 纳米银 卡波姆 抗菌性能 溶胀性能 

分 类 号：O635[理学—高分子化学]