蚯蚓提取物治疗原发性肾小球疾病高凝状态  

Study of treatment effect of earthworm extract on hypercoagulation of primary glomerular disease

作　　者：邵凤民[1] 张小玲[1] 程银桢[1] 王小阳[2] 朱长连[2] 邢清和 张明轩 

机构地区：[1]河南省人民医院肾内科,郑州450003 [2]河南医科大学三附院儿科,郑州450052 [3]河南医科大学三附院药剂科,郑州450052 [4]河南医科大学一附院肾内科,郑州450052

出　　处：《中国临床药学杂志》1999年第6期363-365,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的:探讨蚯蚓提取物对原发性肾小球疾病中凝血、抗凝、纤溶功能及血液流变学的影响.方法:对36例原发性肾病综合征和30例慢性肾小球肾炎给予po蚯蚓提取物150mg/次,tid,连用14d,在用药前后采血测定凝血、抗凝、纤溶及血液流变学指标.结果:治疗后血KPTT、PT、TT较治疗前明显延长(P<0.01、P<0.05),AT-Ⅲ及t-PA活性在治疗后较治疗前明显升高(P<0.001,P<0.01),FDP含量较治疗前也明显上升(P<0.01),血液流变学指标较治疗前均有显著改善(P<0.05、P<0.01).结论:蚯蚓提取物具有抗凝、纤溶的功能,po蚯蚓提取物能改善肾小球疾病的高凝状态.AIM:To explore the influence of earthworm extract on coagulation,anticagu-lation,fibrinolysis and blood viscosity of primary glomerular disease. METHODS:Thirty-six cases of primary nephrotic symdrone (PNS)and 30 cases of chronic glomerulonephrtis (CGN) were given earthworm extract 150 mg/time ,tid,for 14 d. The parameters of coagulation .anticoagulation. fibrinolysis and blood viscosity were measured before and after treatment. RESULTS: KPTT, PT, TT were prolonged markedly after treatment (P<0.01,P< 0. 05). The activity of AT-III t-PA were increased markedly after treatment (P<0. 01,P< 0. 01). Fibrinogen was lower markedly(P<0. 05)than that before treatment. All the parameters of blood viscosity were changed markedly after treatment (P<0. 05,P<0. 01). CONCLUSION : Earth worm extract has the effect of anticoagulation and fibrinolysis. Hypercoagu-lated state of glomerular disease was improved after given,po,earthworm extract.

关 键 词：蚯蚓提取物 肾小球肾炎 高凝状态 肾小球疾病 

分 类 号：R692.310.5[医药卫生—泌尿科学] R692.605[医药卫生—外科学]