心肌细胞膜与肌质网膜的结构功能耦联及其病理重塑机制  

The structural and functional coupling between plasma membrane and sarcoplasmic reticulum in cardiac cells and its remodeling in heart diseases

作　　者：吴昊迪[1] 王世强[1] 孟旭[2] 张海波[2] 

机构地区：[1]北京大学生命科学学院,北京100871 [2]首都医科大学附属北京安贞医院,北京100029

出　　处：《生命科学》2011年第11期1088-1094,共7页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(30800475;30730013);国家重点基础研究发展计划("973"项目)(2011CB809101)

摘　　要：心脏的收缩功能依赖心肌细胞膜(包括横管)与肌质网的结构耦联以及其中L型钙通道与肌质网钙释放通道之间的钙致钙释放过程。在一些病理条件下,细胞膜与肌质网的耦联结构发生重塑,钙致钙释放机制受损,心肌细胞收缩力下降。其中,junctophilin-2等蛋白分子表达量减少是心力衰竭疾病中心肌细胞收缩能力下降的关键因素。The contractile power of the heart depends on the structural coupling between sarcolama（including T-tubules） and sarcoplasmic reticulum（SR）,which enables the Ca2＋-induced Ca2＋ release（CICR） between L-type Ca2＋ channels and SR Ca2＋ release channels.During the pathogenesis of some heart disease,the coupling structure between plasma membrane and SR undergoes remodeling,which compromises the efficiency of CICR,leading to impaired cardiac.Among the underlying molecular mechanisms,the down-regulation of junctophilin-2 expression is a key factor that decreases the contractile power of cardiomyocytes during heart failure.

关 键 词：横管 肌质网 兴奋收缩耦联 钙致钙释放 心衰 junctophilin-2 

分 类 号：R542[医药卫生—心血管疾病]