医院感染高发科室耐甲氧西林金黄色葡萄球菌的耐药性分析  

Analysis of antibiotic resistance of methicillin-resistant Staphylococcus aureus isolated from nosocomial departments with higher infection rate

作　　者：纵帅[1] 贾伟[2] 赵志军[2] 徐广贤[1] 李刚[2] 师志云[2] 魏军[2] 

机构地区：[1]宁夏医科大学检验学院,宁夏银川750004 [2]宁夏医科大学附属医院医学实验中心,宁夏银川750004

出　　处：《中华医院感染学杂志》2011年第23期5074-5076,共3页Chinese Journal of Nosocomiology

基　　金：宁夏回族自治区重大科技攻关计划项目(2008);宁夏自然科学基金资助项目(NZ0667;NZ10132)

摘　　要：目的研究医院感染高发科室分离的耐甲氧西林金黄色葡萄球菌(MRSA)的耐药性,为医院MRSA感染的预防和治疗提供参考。方法对医院感染高发科室分离的MRSA进行耐药性检测,并分析其耐药性特点等。结果 MRSA检出率为62.4%,对所选用的21种抗菌药物中的β-内酰胺类100.0%耐药,对万古霉素、利奈唑胺和替考拉宁100.0%敏感;有87.8%的红霉素耐药、克林霉素敏感MRSA株为红霉素诱导克林霉素耐药表型。结论该次试验分离获得的MRSA表现为较为严重的多药耐药性,未发现对万古霉素耐药或中介的菌株;D-试验结果有助于临床合理选用大环内酯类抗菌药物。OBJECTIVE To investigate the antibiotic resistance of methicillin-resistant Staphylococcus aureus（MRSA） isolated from the nosocomial departments with the higher infection rate,and provide a scientific basis and reference for prevention and control of MRSA infections. METHODS The antibiotics susceptibility tests were performed by the disk diffusion test and the results were analyzed in order to find out their characteristics. RESULTS The detection rate of MRSA strains in S.aureus（SAU） accounted for 62.4%.The resistance rate to all β-lactam antibiotics we selected for this experiment was 100.0%.All MRSA strains were sensitive to vancomycin,linezolid and teicoplanin.The positive rate of D-test in MRSA strains was 87.8% of which were resistant to erythromycin but sensitive to clindamycin. CONCLUSIONS MRSA shows multiple antibiotic resistance,but no isolates are resistant or intermediate to vancomycin in our experiment.The result of D-test can help the physicians to select macrolide antibiotics reasonably.

关 键 词：耐甲氧西林金黄色葡萄球菌 耐药性 E-试验 D-试验 

分 类 号：R378.11[医药卫生—病原生物学]