2009-2010年临床分离细菌耐药性监测  

Drug resistance monitoring of clinical isolates during 2009-2010

作　　者：刘小华[1] 温善华[1] 吕志英[1] 刘先林[1] 李云[1] 

机构地区：[1]江西省兴国县人民医院检验科,江西兴国县342400

出　　处：《中华医院感染学杂志》2011年第23期5080-5082,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解医院2009-2010年临床分离细菌对常见抗菌药物的耐药性。方法采用珠海迪尔医学细菌测定系统软件,药敏试验采用MIC法,对两年医院临床分离菌株进行回顾性总结分析。结果 2009-2010年共分离出1586株细菌,革兰阴性杆菌占64.9%,其中大肠埃希菌、肺炎克雷伯菌和奇异变形菌产ESBLs检出率平均为69.5%、48.5%和4.5%;革兰阳性球菌占35.1%,其中耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)阳性率平均为58.5%和46.6%;分离率排前5位的依次是大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌、金黄色葡萄球菌、凝固酶阴性葡萄球菌;革兰阴性杆菌对亚胺培南最敏感,未发现对万古霉素中介及耐药的葡萄球菌,革兰阴性杆菌和革兰阳性球菌均存在不同程度的耐药。结论医院应加强对细菌分布及耐药性的监测,合理使用抗菌药物,减少多药耐药菌及泛耐药菌株的发生及传播。OBJECTIVE To understand the drug resistance of clinical isolates to common antibiotics in our hospital during 2009-2010. METHODS A medical bacteria detection system from Zhuhai DL Medical Biotech Co.LTD was used,and the MIC method was used for susceptibility testing,to retrospectively analyze clinical isolates in the past two years. RESULTS A total of 1586 pathogenic bacteria were isolated during 2009-2010.Among them,Gram-negative bacilli accounted for 64.9%,of which the detection rates of Escherichia coli,Klebsiella pneumoniae and ESBLs-producing Proteus mirabilis were 69.5%,48.5% and 4.5%,respectively.Gram-positive cocci accounted for 35.1%,in which the positive rates of methicillin-resistant Staphylococcus aureus（MRSA） and methicillin-resistant coagulase-negative staphylococci（MRCNS） were 58.5% and 46.6% respectively.The top five isolation rates were E.coli,Pseudomonas aeruginosa,K.pneumoniae,Staphylococcus aureus,and S.epidermidis.Gram-negative bacteria were most sensitive to imipenem.No vancomycin intermediate and resistant-Staphylococcus were found.Gram-negative bacilli and Gram-positive cocci had varying degrees of drug resistance. CONCLUSION The bacterial resistance monitoring shows that hospitals should enhance the monitoring of pathogenic bacteria distribution and drug resistance,and antibiotics should be rationally used to reduce bacterial multi-drug resistance and the development and transmission of extensively drug-resistant strains.

关 键 词：细菌 耐药性监测 抗菌药物 药敏试验 

分 类 号：R378[医药卫生—病原生物学]