甲型肝炎灭活疫苗免疫原性的猴体实验  

Experimental Study on Immunogenicity of Inactivated Hepatitis A Vaccine in Monkeys

作　　者：李成明[1] 陈江婷[2] 万宗举[1] 崔俊生[2] 练幼辉[3] 尹红章[1] 赵伟[2] 黄小芩 王祥[3] 陈统球[3] 尹卫东[2] 

机构地区：[1]中国药品生物制品检定所,北京100050 [2]唐山怡安生物工程有限公司 [3]中国医学科学院医学生物学研究所

出　　处：《中国生物制品学杂志》1999年第4期221-224,共4页Chinese Journal of Biologicals

摘　　要：甲型肝炎病毒TZ84毒株经 2BS二倍体细胞培养制备成甲型肝炎灭活疫苗。采用普通狨猴和恒河猴进行疫苗的保护性研究。结果均有较好的抗体反应 ,而且对甲型肝炎病毒鲁兴株 (强毒株 )的攻击亦均有保护作用。表明该疫苗有较好的免疫效果。Inactivated hepatitis A(HA) vaccine was prepared by culturing the strain TZ84 of HA virus in 2BS cells, and the immunogencity of it was studied in common marmosets and Macaca mulattas. The result showed that good antibody respones were induced in the 2 kinds of monkeys. The vaccine could also protect the monkeys from the challenge with strong virus strain(Luxing). It indicated that the inactivated HA vaccine had good immunological effect.\;

关 键 词：甲型肝炎 灭活疫苗 普通狨猴 恒河猴 免疫原性 

分 类 号：R392－33[医药卫生—免疫学] R512.610.3[医药卫生—基础医学]