左旋聚乳酸/氟尿嘧啶复合纳米纤维膜的制备  

Preparation of PLLA/FU composite nanofiber film

作　　者：魏安方[1,2] 王娟[3] 凤权[2] 汪学骞[2] 魏取福[1] 侯大寅[2] 

机构地区：[1]江南大学纺织服装学院,江苏无锡214122 [2]安徽工程大学纺织服装学院,安徽芜湖241000 [3]皖南医学院药理教研室,安徽芜湖241000

出　　处：《纺织学报》2011年第12期6-9,共4页Journal of Textile Research

基　　金：国家自然科学基金资助项目(51006046);教育部博士点基金项目(20090093110004);安徽省高校自然科学研究项目(KJ2010B025);安徽省高校自然基金重点项目(KJ2009A119)

摘　　要：为研制一种具有缓释作用的药物纤维膜,拟通过静电纺丝的方法制备出左旋聚乳酸/氟尿嘧啶复合纳米纤维膜,考察了左旋聚乳酸质量分数、添加的氟尿嘧啶质量分数对复合纳米纤维成型性的影响,并对其力学性能以及润湿性能进行了测试与分析。结果表明:随着左旋聚乳酸质量分数的增加,纳米纤维直径变粗,随着添加氟尿嘧啶质量分数的增加,纤维直径变细。力学性能测试表明,复合纳米纤维膜的断裂强力、断裂功及断裂强度随着药物添加质量分数的增加而减小。润湿性能测试表明,复合纳米纤维膜的亲水性随着药物添加质量分数的增加而增加,同时,复合膜的异质不均匀性也随之增加。In order to develop one kind of fiber film with sustained drug delivery,poly（L-lactic acid）/flurouracil（PLLA/FU） composite nanofiber film were prepared by electrospinning.The influence of mass fraction of PLLA and relative ratios of fluorouracil on the morphology of the composite nanofibers was discussed.The mechanical properties and surface wettability were also studied.The results showed the diameter of the composite nanofibers increased with the increase of PLLA mass fraction,whereas their diameter decreased with the increase of ratio of fluorouracil.The mechanical performance test showed the tensile strength,rupture work and breaking strength of the composite nanofiber film decreased with the increase of mass fraction of the added drug.The wetting property test showed the wettability of the composite nanofiber film increased with the increase of mass fraction of the added drug,but their heterogeneity was also increased.

关 键 词：静电纺丝 复合纳米纤维膜 左旋聚乳酸 氟尿嘧啶 

分 类 号：TS102.1[轻工技术与工程—纺织工程]