RNAi:基因功能研究新途径  

RNAi: new pathway for study of gene funcion

作　　者：曹新[1] 黄赞[1] 

机构地区：[1]上海市儿童医院上海医学遗传研究所,上海200040

出　　处：《生命科学》1999年第6期278-281,272,共5页Chinese Bulletin of Life Sciences

摘　　要：随着基因组结构深入研究，应用新的方法、思路探讨细胞基因功能已成必要。已证实：双链RNA（double－strandRNA，dsRNA）在多种生物中是导致细胞基因沉默（genesilencing）的重要信号分子。dsRNA介导的基因阻抑（RNAinterference，RNAi）现象是反映基因功能、表达调控、缺陷识别等重要手段。dsRNA介导阻抑特异基因表达的机制还不清楚。In the progress of the genome projects, the usage of new pathways and ideas infunction of cellular gene is very important. It has been demonstrated that double-strand RNA(dsRNA) is a signal for gene-specific silencing of expression in a number of organisms. The RNAinterference (RNAi) phenomenon is likely to be an essential method for gene function activity、regulation and control、 recognization of genetic defect. The mechanisms for dsRNA-mediatedinterference of specific-gene expression is still not very clear.

关 键 词：双链RNA 阻抑 基因调控 基因表达 基因功能 

分 类 号：Q522[生物学—生物化学] Q756