人参皂苷水溶液热稳定性研究  

Studies on Thermal Stability of Ginsenosides Aqueous Solution

作　　者：余潇苓[1] 苗青[1] 方翠芬[2] 

机构地区：[1]浙江中医药大学附属第一医院,杭州310006 [2]浙江省食品药品检验所,杭州310004

出　　处：《中国现代应用药学》2011年第12期1109-1112,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 研究加热时间对人参皂苷水溶液的影响及受热后人参皂苷含量的变化情况。方法 红参须浓缩液加热不同时间，采用高效液相色谱法测定其人参皂苷Rg1、Re、Rb1、Rc和Rd的含量。结果 5种人参皂苷在加热6 h内，发生不同程度的降解反应，二醇类人参皂苷Rb1、Rc和Rd在加热2-3 h时，含量呈明显下降趋势，人参皂苷Rd降解速率最慢。三醇类人参皂苷Rg1和Re在加热3 h内含量快速下降，3 h后趋于平缓。结论 在常压受热条件下，人参皂苷水溶液主要成分人参皂苷Rg1、Re、Rb1、Rc和Rd的含量，随加热时间延长而不断下降，3 h后下降速率减缓。三醇类人参皂苷较二醇类对热更为敏感。OBJECTIVE To research the influence of heating-time on ginsenosides aqueous solution. METHODS HPLC was applied to determine the contents of ginsenoside Rg1, Re, Rb1, Rc and Rd, by means of different heating-time in Radix ginseng laterialis rubra concentrated liquid. RESULTS Within 6 hour of heating, the five types of ginsenosides showed different degrees of degradation. The content of the 20（S）-protopanaxdiol type ginsenoside Rb1, Rc and Rd decreased significantly in the first 2 to 3 hours. Ginsenoside Rd had the lowest degradation rate compare with other four ginsenosides. The 20（S）-protopanaxtriol type ginsenoside Rg1 and Re decreased rapidly within the first 3 hours, and then leveled off. CONCLUSION Under heating at atmospheric pressure, the main ingredients of in ginsenosides, Rg1, Re, Rb1, Rc and Rd, will keep falling as the heating prolonged. The descent rate becomes slow after the first 3 hours. Specifically, 20（S）-protopanaxtriol type ginsenoside is more sensitive than 20（S）-protopanaxdiol type ginsenoside.

关 键 词：人参皂苷 稳定性 降解 高效液相色谱法 

分 类 号：R285.1[医药卫生—中药学]